Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests.

BMC Complementary and Alternative Medicine
Jianling JinPeiji Gao

Abstract

Semen armeniacae amarum (SAA) is a Chinese traditional medicine and has long been used to control acute lower respiratory tract infection and asthma, as a result of its expectorant and antiasthmatic activities. However, its mutagenicity in vitro and in vivo has not yet been reported. The Ames test for mutagenicity is used worldwide. The histidine contained in biological samples can induce histidine-deficient cells to replicate, which results in more his+ colonies than in negative control cells, therefore false-positive results may be obtained. So, it becomes a prerequisite to exclude the effects of any residual histidine from samples when they are assayed for their mutagenicity. Chinese traditional herbs, such as SAA, are histidine-containing biological sample, need modified Ames tests to assay their in vitro mutagenicity. The mutagenicity of SAA was evaluated by the standard and two modified Ames tests. The first modification used the plate incorporation test same as standard Ames teat, but with new negative control systems, in which different amounts of histidine corresponding to different concentrations of SAA was incorporated. When the number of his+ revertants in SAA experiments was compared with that in new negative contr...Continue Reading

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Citations

Aug 12, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Hwan-Suck ChungHyunsu Bae
Aug 21, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Mei Ling ChenJian Ling Jin
Apr 23, 2013·Journal of Ethnopharmacology·Youn-Hwan HwangJin Yeul Ma
Dec 3, 2016·BMC Complementary and Alternative Medicine·Tshepiso Jan MakhafolaJacobus Nicolaas Eloff
Mar 24, 2021·South African Journal of Botany : Official Journal of the South African Association of Botanists = Suid-Afrikaanse Tydskrif Vir Plantkunde : Amptelike Tydskrif Van Die Suid-Afrikaanse Genootskap Van Plantkundiges·Aitebiremen Gift Omokhua-Uyi, Johannes Van Staden
Apr 6, 2021·Journal of the American College of Emergency Physicians Open·Michael A DiPietro, Christopher Mondie

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Methods Mentioned

BETA
chromosomal aberration
chromosomal aberrations

Software Mentioned

Origin
SPSS

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