PMID: 589701Nov 1, 1977

Mutagenicity of dichloroacetaldehyde and 2,2-dichloro-1,1-dihydroxy-ethanephosphonic acid methyl ester, possible metabolites of the organophosphate pesticide Trichlorphon

Chemico-biological Interactions
G W FischerH Scheufler

Abstract

Dichloroacetaldehyde and 2,2-dichloro-1,1-dihydroxy-ethanephosphonic acid methyl ester which are formed solvolytically from desmethyltrichlorphone, an in vivo metabolite of the organophosphorus pesticide Trichlorphone, show in the dominant lethal test in mice at equimolar dosage (1.6 mmol/kg) a mutagenic activity comparable with that of Trichlorphon. Therefore it cannot be ruled out that the genetic effects of this pesticide may be due in part to the action of its degradation products.

Citations

Apr 23, 1979·Archives of Toxicology·A S WrightM F Wooder
Feb 1, 1991·Japanese Journal of Cancer Research : Gann·P C ChanJ D Prejean
Aug 26, 1998·Drug Metabolism Reviews·P W StacpooleM O James
Jan 1, 1981·Clinical Toxicology·M D Reuber
Jan 1, 1981·Acta Pharmacologica Et Toxicologica·J Moutschen-DahmenN Degraeve

Related Concepts

Metazoa
Genes, Dominant
Alleles, Lethal
Clastogens
Ricifon
Mouse, Swiss

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