PMID: 6991921Mar 1, 1980Paper

Mutagenicity of nifurtimox in Escherichia coli

Mutation Research
T OhnishiS Inoki

Abstract

The effects of nifurtimox, a nitrofuran derivative, on killing and mutation induction in 3 Escherichia coli strains having different DNA-repair systems for UV lesion were studied and compared with the effects of furylfuramide. Nifurtimox induces mutations at a high frequency in both Hs3OR (uvrA-) and H/r30R (radiation-resistant), although no significant killing effect is detected with Hs30R. No significantly induced mutation frequency could be detected with NG30 (recA-), which is very sensitive to killing by nifurtimox. The characteristics of lesions of DNA induced by nifurtimox and the mechanism of mutation induction in Hs30R are discussed.

References

Feb 1, 1974·Mutation Research·D R McCalla, D Voutsinos
Apr 24, 2009·Proceedings of the American Thoracic Society·Homer A Boushey

❮ Previous
Next ❯

Citations

May 1, 1983·Mutation Research·R Nagel, I Nepomnaschy
Jul 1, 1986·Mutation Research·R C Ferreira, L C Ferreira
May 1, 1987·Mutation Research·R Nagel
Jul 1, 1987·Mutation Research·T OhnishiK Nozu
Apr 18, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M J IatropoulosG M Williams
Jan 1, 1983·Environmental Mutagenesis·D R McCalla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.