PMID: 7022189Aug 1, 1981Paper

Mutagenicity of nitro derivatives induced by exposure of aromatic compounds to nitrogen dioxide

Mutation Research
H TokiwaY Ohnishi

Abstract

Mutagenic nitro derivatives were readily induced when 6 kinds of chemicals were exposed to 10 ppm of nitrogen dioxide (NO2). Single nitro derivatives were formed from pyrene, phenanthrene, fluorene or chrysene. Carbazole and fluoranthene each produced 2 derivatives substituted with nitro groups at different positions. The formation of nitro derivatives was enhanced by exposure of pyrene to NO2 containing nitric acid (HNO3, less than 100-fold enhancement) or sulphur dioxide (SO2, less than 15-fold enhancement). After 24 h of exposure the yields of the nitro derivative were 0.02% with 1 ppm of NO2 in air and 2.85% with NO2 (1 ppm) containing traces of HNO3. The nitro derivatives from all but phenanthrene and carbazole were chemically identified by means of gas chromatography (GC) and mass spectrometry (MS), and the mutagenicity of the 4 kinds of authentic nitro derivatives was tested by using Salmonella strains TA98 and TA1538 with or without the S9 fraction from rat liver treated with Aroclor 1254. The nitro derivative induced from pyrene was determined to be 1-nitropyrene; that of chrysene was 6-nitrochrysene; that of fluorene was 2-nitrofluorene; and those of fluoranthene were 3-nitrofluoranthene, and 8-nitrofluoranthene. Test...Continue Reading

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Citations

May 1, 1986·Bulletin of Environmental Contamination and Toxicology·N Takeda, K Teranishi
Oct 1, 1984·Bulletin of Environmental Contamination and Toxicology·N TakedaK Hamada
Sep 1, 1988·Mutation Research·B Beije, L Möller
Sep 1, 1993·Mutation Research·H TokiwaY Ohnishi
Feb 1, 1994·Mutation Research·K Victorin
Oct 1, 1982·Mutation Research·H FukinoY Yamane
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Aug 1, 1986·Mutation Research·M A McCartneyH S Rosenkranz
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Mar 17, 2011·Environmental Science & Technology·Takayuki KamedaKazuichi Hayakawa
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