Mutagenicity of photochemical reaction products of polycyclic aromatic hydrocarbons with nitrite

The Science of the Total Environment
T Ohe


Six kinds of polycyclic aromatic hydrocarbons (PAHs) were subjected to ultraviolet light irradiation with nitrite for 1, 4, 8 and 24 h, and the irradiated samples were tested for mutagenicity towards Salmonella typhimurium TA 98, TA 100 and TA 1538. Irradiated samples of pyrene, fluoranthene and benzo[a]pyrene showed marked mutagen responses towards TA 98 and TA 1538, especially in the absence of S9 mix. The direct-acting mutagenic activity of these samples, showing high activities at 1-8 h, decreased greatly with the development of irradiation. Further, these direct-acting mutagens were mostly present in the neutral fraction. On the other hand, the mutagenicity of the irradiated sample of 5,6-benzoquinoline was high both with and without S9 mix, and was mostly present in the basic fraction because of its authentic characteristic. There was no correlation between the yield of 1-nitropyrene and the mutagenic activity of the photochemical reaction product of pyrene with nitrite. Further studies by TLC separation suggested that a considerable number of direct-acting mutagens formed in this experiment were more polar than nitrated PAH such as 1-nitropyrene.


Jul 1, 1978·Cancer Letters·Y Y WangE T Wei
Apr 1, 1977·Mutation Research·H TokiwaY Ohnishi
Feb 1, 1978·Mutation Research·T L GibsonL L Smith
Mar 1, 1980·Mutation Research·Y OhnishiH Tokiwa
Oct 1, 1981·Bulletin of Environmental Contamination and Toxicology·J P NachtmanE T Wei
Mar 1, 1982·Mutation Research·H S Rosenkranz
Mar 1, 1982·Mutation Research·Y OhnishiK Furuya
Jan 1, 1983·Environmental Health Perspectives·I AlfheimM Møller
Jan 1, 1983·Environmental Health Perspectives·D Schuetzle
Jul 1, 1983·Bulletin of Environmental Contamination and Toxicology·J SuzukiS Suzuki
Oct 1, 1982·Mutation Research·H FukinoY Yamane
Mar 1, 1983·Mutation Research·M MøllerE Agurell
Feb 1, 1980·Mutation Research·H TokiwaY Ohnishi
Aug 29, 1980·Science·G LöfrothM Møoller
Sep 1, 1980·Mutation Research·C E Chrisp, G L Fisher
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Sep 1, 1981·Mutation Research·E C McCoyR Mermelstein
Jan 1, 1982·Cancer Letters·E C McCoy, H S Rosenkranz
Nov 1, 1982·Bulletin of Environmental Contamination and Toxicology·J SuzukiS Suzuki
Dec 1, 1980·Environmental Science & Technology·S M RappaportH Rapoport

❮ Previous
Next ❯


Sep 1, 1988·Mutation Research·B Beije, L Möller
Aug 8, 2008·Bioscience, Biotechnology, and Biochemistry·Tomoyasu ToyoizumiNaohide Kinae
Oct 1, 1993·Environmental Health Perspectives·L MöllerL C Eriksson
Oct 1, 1994·Environmental Health Perspectives·L Möller
Oct 21, 2014·Environmental and Molecular Mutagenesis·Elena R KisinAnna A Shvedova
Aug 9, 2012·Critical Reviews in Toxicology·Jürgen BüngerGötz A Westphal
Mar 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·M S ShailajaSolimabi Wahidulla

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.