Mutagenicity of photochemical reaction products of polycyclic aromatic hydrocarbons with nitrite

The Science of the Total Environment
T Ohe

Abstract

Six kinds of polycyclic aromatic hydrocarbons (PAHs) were subjected to ultraviolet light irradiation with nitrite for 1, 4, 8 and 24 h, and the irradiated samples were tested for mutagenicity towards Salmonella typhimurium TA 98, TA 100 and TA 1538. Irradiated samples of pyrene, fluoranthene and benzo[a]pyrene showed marked mutagen responses towards TA 98 and TA 1538, especially in the absence of S9 mix. The direct-acting mutagenic activity of these samples, showing high activities at 1-8 h, decreased greatly with the development of irradiation. Further, these direct-acting mutagens were mostly present in the neutral fraction. On the other hand, the mutagenicity of the irradiated sample of 5,6-benzoquinoline was high both with and without S9 mix, and was mostly present in the basic fraction because of its authentic characteristic. There was no correlation between the yield of 1-nitropyrene and the mutagenic activity of the photochemical reaction product of pyrene with nitrite. Further studies by TLC separation suggested that a considerable number of direct-acting mutagens formed in this experiment were more polar than nitrated PAH such as 1-nitropyrene.

References

Jul 1, 1978·Cancer Letters·Y Y WangE T Wei
Apr 1, 1977·Mutation Research·H TokiwaY Ohnishi
Feb 1, 1978·Mutation Research·T L GibsonL L Smith
Mar 1, 1980·Mutation Research·Y OhnishiH Tokiwa
Oct 1, 1981·Bulletin of Environmental Contamination and Toxicology·J P NachtmanE T Wei
Mar 1, 1982·Mutation Research·H S Rosenkranz
Mar 1, 1982·Mutation Research·Y OhnishiK Furuya
Jan 1, 1983·Environmental Health Perspectives·I AlfheimM Møller
Jan 1, 1983·Environmental Health Perspectives·D Schuetzle
Jul 1, 1983·Bulletin of Environmental Contamination and Toxicology·J SuzukiS Suzuki
Oct 1, 1982·Mutation Research·H FukinoY Yamane
Mar 1, 1983·Mutation Research·M MøllerE Agurell
Feb 1, 1980·Mutation Research·H TokiwaY Ohnishi
Aug 29, 1980·Science·G LöfrothM Møoller
Sep 1, 1980·Mutation Research·C E Chrisp, G L Fisher
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Sep 1, 1981·Mutation Research·E C McCoyR Mermelstein
Jan 1, 1982·Cancer Letters·E C McCoy, H S Rosenkranz
Nov 1, 1982·Bulletin of Environmental Contamination and Toxicology·J SuzukiS Suzuki
Dec 1, 1980·Environmental Science & Technology·S M RappaportH Rapoport

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Citations

Sep 1, 1988·Mutation Research·B Beije, L Möller
Aug 8, 2008·Bioscience, Biotechnology, and Biochemistry·Tomoyasu ToyoizumiNaohide Kinae
Oct 1, 1993·Environmental Health Perspectives·L MöllerL C Eriksson
Oct 1, 1994·Environmental Health Perspectives·L Möller
Oct 21, 2014·Environmental and Molecular Mutagenesis·Elena R KisinAnna A Shvedova
Aug 9, 2012·Critical Reviews in Toxicology·Jürgen BüngerGötz A Westphal
Mar 15, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·M S ShailajaSolimabi Wahidulla

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