PMID: 6991694Apr 1, 1980Paper

Mutagenicity of substituted (o-phenylenediamine)platinum dichloride in the Ames test. A quantitative structure-activity analysis

Journal of Medicinal Chemistry
C HanschA Panthananickal

Abstract

A set of 13 substituted (o-phenylenediamine)platinum dichlorides has been studied in the Ames test using Salmonella typhimurium (TA-92). These cis-platinum compounds are mutagenic without activation by microsomes. The following correlation equation shows that the most important determinant of mutagenicity by substituents (X) is electron withdrawal via through resonance: log 1/C = 2.23 sigma sigma minus + 5.78. C in this expression is the molar concentration of compound producing 30 mutations/10(8) bacteria initially delivered above background mutation, and sigma minus is the Hammett constant obtained from substituted anilines.

Citations

Dec 1, 1996·Journal of Computer-aided Molecular Design·E Yuriev, J D Orbell
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·M JennerweinR Osieka
Jun 1, 1993·Mutation Research·K Tuppurainen, S Lötjönen
Jan 1, 1984·Drug Metabolism Reviews·C Hansch
Jan 1, 1990·Environmental and Molecular Mutagenesis·R L Lopez de CompadreC Hansch
Jan 29, 2019·Nucleosides, Nucleotides & Nucleic Acids·Navaneetha NambagariS Satyanarayana
Jan 1, 1986·Environmental Mutagenesis·M R FriersonH S Rosenkranz
Jun 12, 2021·Journal of Inorganic Biochemistry·Zhifan LiuZhigang Zhang

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