PMID: 6990252Apr 1, 1980Paper

Mutagenicity of sulphonylureas

Mutation Research
H W Renner, R Münzner

Abstract

The 11 derivatives of beta-cytotropic sulphonylureas commonly used in the treatment of diabetes mellitus were tested in vivo in the highly sensitive sister-chromatid exchange test. Chlorpropamide and tolbutamide gave a positive reaction with a clear dose-response in Chinese hamsters and mice. The two compounds gave a mutagenic response neither in the Salmonella/mammalian-microsome mutagenicity test (with and without microsomal activation) nor in the chromosomal aberration test. In the micronucleus test, chlorpropamide was positive in 3 strains of mouse, tolbutamide in one strain. In Chinese hamsters and in rats the micronucleus test was negative with both compounds.

References

Nov 1, 1976·Mutation Research·P Maier, W Schmid
Jan 1, 1979·Journal of Toxicology and Environmental Health·M F Festing
Sep 1, 1978·Clinical Pediatrics·Z Laron
Feb 1, 1976·Mutation Research·W A WatsonJ C Gilbert
Mar 1, 1977·The Journal of Clinical Endocrinology and Metabolism·J W BensonJ W Ensinck

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Citations

Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Jun 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P S KulkarniS D Bhandarkar
Jan 1, 1981·Experimental Pathology·A Basler, G Röhrborn
May 2, 2006·Acta Biologica Hungarica·F Kaymak, F D Gökalp Muranli
Aug 24, 2012·Toxicology and Industrial Health·Mehmet GürbüzelLevent Demirtaş
Jan 1, 2008·Clinical Medicine. Oncology·Syed Imam RabbaniSalma Khanam
Jun 6, 2009·Chemico-biological Interactions·S M AttiaA A Alhaider

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