PMID: 7007875Dec 1, 1980Paper

Mutagenicity of trialkyltriazenes: mutagenic potency of alkyldiazonium ions, the putative ultimate carcinogens from dialkylnitrosamines

Mutation Research
D H SiehC J Michejda

Abstract

Although aryldialkyltriazenes have been known for many years and their mutagenic, carcinogenic and carcinostatic properties have been investigated, almost nothing is known of the related trialkyltriazenes. Our recently developed general preparative route to these substances has allowed the examination of the mutagenic properties of several representative examples of this class of compounds. This, 1-benzyl-3,3-dimethyl-, 3-benzyl-1,3-dimethyl, 3-benzyl-3-methyl-1-n-butyl- and 1,3-di-n-butyl-3-methyltriazenes are direct acting mutagens in the TA1535 strain of Salmonella typhimurium. The respective mutagenic potencies of these substances can be accounted for by the in situ generation of alkyldiazonium ions. These ions are considered to be strong candidates for the ultimate mutagens/carcinogens derived from some dialkylnitrosamines.

References

Mar 1, 1979·Mutation Research·H F ThomasZ Hartman
May 1, 1979·Journal of Medicinal Chemistry·B H VengerY U Amrein
Aug 7, 1978·Acta Neuropathologica·H K CooperP Kleihues
Feb 1, 1976·Biochemical Pharmacology·T A ConnorsD E Wilman
Sep 1, 1971·Zeitschrift Für Naturforschung. Teil B. Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie·G F Kolar, R Preussmann
Nov 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·D A CLARKEC S RONDESTVEDT

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Citations

Jan 1, 1985·Pharmacology & Therapeutics·A DippleE K Weisburger
Sep 1, 1987·Mutation Research·J B Guttenplan

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