Jan 1, 1982

Mutagenicity of urine from nurses handling cytostatic drugs, influence of smoking

International Archives of Occupational and Environmental Health
R P BosP T Henderson

Abstract

Mutagenicity towards Salmonella typhimurium TA 100 of urine from smoking nurses, who were occupationally involved in the treatment of patients with cytostatic drugs, was significantly increased in comparison with that of smoking control subjects. Mutagenicity towards Salmonella typhimurium TA 100 was not increased in exposed non-smokers when compared to control non-smokers. In smoking subjects urinary mutagenicity appeared increased towards Salmonella typhimurium TA 1538 in the presence of S-9 mix. Rats pretreated with Aroclor 1254 showed higher mutagenicity in their urine than untreated rats after cyclophosphamide administration. Therefore, the synergistic effect of smoking might be due in part to induction of enzymes involved in the mutagenic activation of cytostatic drugs. Further, the animal experiments showed that cyclophosphamide (the most frequently used mutagenic cytostatic drug) can be absorbed after oral or percutaneous administration. Therefore, it is not excluded that differences in working hygiene between smokers and non-smokers also play a role.

  • References13
  • Citations59

Mentioned in this Paper

Urine
Antineoplastic Agents
Cyclophosphamide
Enzymes, antithrombotic
Mutagenicity Tests
Cytostatic Agents
Enzymes for Treatment of Wounds and Ulcers
Salmonella typhimurium
Urine - SpecimenType
Aroclor-1254

About this Paper

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