PMID: 6987507Jan 1, 1980Paper

Mutagenicity studies with nitrofurans. II. mutagenicity of nitrofurylacrylic acid for Salmonella typhimurium

Mutation Research
M Cerná, R J Srám

Abstract

The mutagenicity of 3-(5-nitro-2-furyl)acrylic acid (5-NFA) for Salmonella typhimurium tester strains TA100, TA98, TA1535 and TA1950 was studied by using the spot test, liquid-incubation test, microsomal assay, host-mediated assay and mutagenic analysis of blood and urine from treated mice. 5-NFA was dissolved in physiological saline or 10% ethanol. In the spot test, mutagenicity was found with TA100 and TA98 tester strains. A dose-related increase in mutation frequency was observed in the liquid-incubation test (at concentrations ranging from 1 to 50 micrograms 5-NFA/ml) with TA100 and TA1535; TA100 was the more sensitive. The use of ethanol reduced bacterial cell survival and increased the frequency of revertants. The Salmonella/microsomal assay showed no difference in mutagenic activity between the 5-NFA samples in tests with and without metabolic activation in vitro. In the host-mediated assay, mutagenicity of 5-NFA was detected after its applications in 3 fractionated doses. Subcutaneously applied 5-NFA was mutagenic after a total dose of 15 mg/kg, and after intragastric application of a total dose of 150 mg/kg. When blood samples from treated mice were analysed, the mutagenicity of 5-NFA at intragastric doses of 75, 150 a...Continue Reading

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