PMID: 7010246Sep 1, 1980Paper

Mutagenicity studies with urine concentrates from coke plant workers

Scandinavian Journal of Work, Environment & Health
M Møller, E Dybing

Abstract

Urine from coke plant workers, collected before and after work, were tested for the content of mutagenic substances in the Salmonella test system. Urine extracts from exposed smokers showed mutagenic activity, whereas urine from exposed nonsmokers did not. The mutagenicity of exposed smoker's urine was not significantly different from that of urine from nonexposed smokers. Mutagenicity of smokers' urine was only evident in the presence of a rat liver metabolic activation system. The addition of beta-glucuronidase did not enhance the mutagenic effect. The facts that coke plant workers are exposed to very high levels of polycyclic aromatic hydrocarbons (PAH) and that there is no observed enhanced mutagenicity of their urine indicate that the mutagenicity observed with urine from smokers is not due to conventional PAH.

Citations

Jan 1, 1982·International Archives of Occupational and Environmental Health·R PasquiniF Fagioli
Jan 1, 1985·International Archives of Occupational and Environmental Health·F J JongeneelenP T Henderson
Jan 1, 1985·International Archives of Occupational and Environmental Health·R PasquiniG Angeli
Jan 1, 1989·International Archives of Occupational and Environmental Health·R PasquiniG Angeli
Jun 1, 1989·Mutation Research·A Krøkje
May 1, 1995·Toxicology Letters·C RossiC Gerbelli
Feb 27, 2004·Occupational and Environmental Medicine·E SiwińskaL Kapka
Oct 1, 1985·British Journal of Industrial Medicine·G AhlborgM Sorsa
Feb 14, 2007·Environmental and Molecular Mutagenesis·Sofia PavanelloErminio Clonfero
Dec 2, 2004·Mutation Research·David M DeMarini
Oct 1, 1985·Journal of Applied Toxicology : JAT·F J JongeneelenP T Henderson
Oct 1, 1983·Environmental Research·R B EversonR S Sandler
Sep 18, 1997·American Industrial Hygiene Association Journal·D MielyńskaJ A Sokal
Jan 1, 1989·Teratogenesis, Carcinogenesis, and Mutagenesis·R PasquiniF Cerami
Jan 1, 1985·Environmental Mutagenesis·R B EversonP D Buchanan
Jan 1, 1991·Environmental Health Perspectives·C J Hogue, M A Brewster
Aug 18, 2018·Journal of Occupational Medicine and Toxicology·Caterina LeddaVenerando Rapisarda

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