Mutagenicity tests with cadmium in the mouse.

Toxicology
N Gilliavod, A Léonard

Abstract

The testicle is known to be the critical organ in acute exposure of experimental mammals to cadmium. Such treatment results in temporary sterility and, very often, in the appearance of testicular interstitial cell tumors. The present experiments were performed to determine whether such deleterious effects on the male reproductive organs involved any genetic hazards for the surviving germ cells. The administration of 1.75 mg/kg cadmium chloride to male mice did not increase the dominant lethals during the first three weeks after treatment and failed to induce translocation in the F1 male off-spring. No chromosome rearrangement was observed in the treated males after i.p. injection of 0.5, 1.75 or 3.0 mg/kg cadmium chloride.

References

Dec 1, 1973·Environmental Research·K NomiyamaS Nakagawa
Sep 1, 1973·Toxicology·A Léonard, N Gilliavod
Nov 1, 1972·Mutation Research·G R Paton, A C Allison
Jun 2, 1956·Nature·J PARIZEK, Z ZAHOR

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Citations

Mar 30, 1976·Radiation and Environmental Biophysics·A Léonard
Mar 1, 1986·Bulletin of Environmental Contamination and Toxicology·B C LakkadB B Chatterjee
Jun 1, 1978·Bulletin of Environmental Contamination and Toxicology·T S Dikshith, S V Chandra
May 1, 1989·Mutation Research·I D Adler, J Ashby
Apr 1, 1980·The Science of the Total Environment·K Nomiyama
Sep 1, 1980·Mutation Research·W M GenerosoE von Halle
Nov 1, 1978·Mutation Research·M L O'RiordanH J Evans
Aug 1, 1979·Mutation Research·T WatanabeA Endo
Jan 1, 1980·Teratogenesis, Carcinogenesis, and Mutagenesis·J B Bishop, R L Kodell
Jan 1, 1981·Mutation Research·N Degraeve

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