Mutagens in coffee and other beverages

Environmental Health Perspectives
M NagaoT Sugimura

Abstract

A cup of coffee contains mutagens which produce about 5 X 10(4)-10(5) revertants of Salmonella typhimurium TA 100 without S9 mix. One of the mutagens was identified to be methylglyoxal. Methylglyoxal was present in various beverages such as black tea, whisky, and brandy. Methylglyoxal itself induced tumors in rats when administered by subcutaneous injection. However, the mutagenic properties of coffee were different from those of methylglyoxal. The mutagenicity of coffee was suppressed by catalase, and coffee was found to contain hydrogen peroxide. Furthermore, coffee solution was found to have a hydrogen peroxide-generating system. Instant coffee (15 mg/mL) contains 130 microM hydrogen peroxide immediately after the dissolution of coffee powder in water at room temperature. The concentration of hydrogen peroxide increased with time. The mutagenicity of methylglyoxal was increased by the copresence of hydrogen peroxide. A maximum of 30-fold enhancement was observed. The mutagenicity of black tea but not that of whisky was suppressed by catalase.

Citations

Aug 16, 2001·Nucleic Acids Research·N Murata-Kamiya, H Kamiya
Sep 1, 2008·Therapeutic Advances in Neurological Disorders·Iris Unterberger, Eugen Trinka
May 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·U GrafE Díaz Carrillo
Mar 23, 2011·Biochemical and Biophysical Research Communications·Saheem AhmadAsif Ali
Jan 13, 2009·Regulatory Toxicology and Pharmacology : RTP·W S RickertJ H Lauterbach
Jan 1, 2008·Chemico-biological Interactions·Miklós Péter Kalapos
Mar 23, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J BichlerS Knasmüller
May 6, 2009·International Journal of Cancer. Journal International Du Cancer·Farhad IslamiFarin Kamangar
Apr 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H U AeschbacherR Liardon
Jan 19, 2006·Critical Reviews in Toxicology·Peter J O'BrienNandita Shangari
Jun 1, 1990·Environmental Research·F J TewesR Rylander
Aug 1, 2014·Applied Biochemistry and Biotechnology·Jalaluddin M AshrafMohammad A Alzohairy
Feb 14, 2017·International Journal of Biological Macromolecules·B VilanovaJ Ortega-Castro
Apr 26, 2008·Molecular Nutrition & Food Research·Matthias BaumGerhard Eisenbrand
Apr 7, 2006·Molecular Nutrition & Food Research·Marc SchneiderMonika Pischetsrieder
Jan 1, 1988·Environmental and Molecular Mutagenesis·B S ShaneC B Henry
Oct 22, 2004·Human Molecular Genetics·Hsien-Yang LeeLouis J Ptácek
Jan 1, 1995·Environmental and Molecular Mutagenesis·S M HouC E Vaca
Jan 1, 1995·Environmental and Molecular Mutagenesis·M A JohanssonJ S Felton
Nov 9, 2020·Journal of Photochemistry and Photobiology. B, Biology·Anal JanaAnimesh Samanta
Aug 18, 2004·Chemical Research in Toxicology·Angela K BrockThomas M Harris
Apr 27, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yiren YueYeonhwa Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved