Mutant alleles of small effect are primarily responsible for the loss of fitness with slow inbreeding in Drosophila melanogaster.

Genetics
B D Latter

Abstract

Multilocus simulation is used to identify genetic models that can account for the observed rates of inbreeding and fitness decline in laboratory populations of Drosophila melanogaster. The experimental populations were maintained under crowded conditions for approximately 200 generations at a harmonic mean population size of Nh approximately 65-70. With a simulated population size of N = 50, and a mean selective disadvantage of homozygotes at individual loci approximately 1-2% or less, it is demonstrated that the mean effective population size over a 200-generation period may be considerably greater than N, with a ratio matching the experimental estimate of Ne/Nh approximately 1.4. The buildup of associative overdominance at electrophoretic marker loci is largely responsible for the stability of gene frequencies and the observed reduction in the rate of inbreeding, with apparent selection coefficients in favor of the heterozygote at neutral marker loci increasing rapidly over the first N generations of inbreeding to values approximately 5-10%. The observed decline in fitness under competitive conditions in populations of size approximately 50 in D. melanogaster therefore primarily results from mutant alleles with mean effects o...Continue Reading

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Citations

Jun 20, 2008·Evolution; International Journal of Organic Evolution·Charles W FoxDavid H Reed
Jan 16, 2008·Journal of Evolutionary Biology·T A White, J B Searle
May 1, 2007·Journal of Evolutionary Biology·C R Haag, D Ebert
May 15, 2007·Molecular Ecology·Thomas A White, Jeremy B Searle
Oct 22, 2020·Genetics, Selection, Evolution : GSE·Julia Poyato-BonillaMercedes Valera
Feb 19, 2021·Evolution; International Journal of Organic Evolution·Donald M Waller
Oct 17, 2009·Nature Reviews. Genetics·Deborah Charlesworth, John H Willis
Nov 1, 2021·Journal of Animal Science·Davinia I Perdomo-GonzálezMercedes Valera

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