PMID: 8464903Apr 1, 1993Paper

Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma

Proceedings of the National Academy of Sciences of the United States of America
C MaoGeorge R Stark

Abstract

Using immunoselection, we have isolated 11 independent mutant HT1080 fibrosarcoma cell lines defective in the induction by interferon gamma (IFN-gamma) of the expression of the human leukocyte antigen HLA-DRA. The mutations are recessive and fall into five complementation groups. All the mutants are affected mainly in the expression of major histocompatibility complex class II and invariant-chain genes. Type I mutants (three complementation groups) are completely defective in induction of the invariant-chain and class II HLA-DP, -DQ, -DR, and -DM genes, whereas type II mutants (two complementation groups) induce these genes weakly in response to IFN-gamma, in the order DPB > DRA > invariant chain. The induction by IFN-gamma of the mRNAs for class I, TAP1, LMP7, and 9-27 is partially defective and the induction of the proteins IRF-1 and ICAM-1 is normal in both types of mutants. All the mutants respond normally to IFN-alpha. The mutants are stable and thus can be used to clone the affected genes by reversion.

References

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Citations

Oct 1, 1994·Pharmacology & Therapeutics·D L Lundell, S K Narula
Oct 1, 1995·Current Opinion in Genetics & Development·V Steimle, B Mach
Sep 1, 1993·Trends in Biochemical Sciences·S Pellegrini, C Schindler
Nov 19, 2003·International Journal of Food Microbiology·Maurizio ViscardiDomenico Iannelli
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Pia Møller Martensen, Just Justesen
Feb 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T OhtaM Kurimoto
Jan 1, 1996·Annual Review of Immunology·B MachW Reith
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·K L WrightJ P Ting
Dec 12, 2012·Cell Metabolism·Marta DereckaAndrew C Larner
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D J TaxmanJ P Ting
Jan 8, 1998·International Journal of Cancer. Journal International Du Cancer·S B HoschK Pantel

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