PMID: 7581164Jul 1, 1995Paper

Mutant mouse strains as models for in vivo radiotracer evaluations: [11C]methoxytetrabenazine ([11C]MTBZ) in tottering mice

Nuclear Medicine and Biology
M R KilbournL C Abbott

Abstract

The regional brain distribution of [11C]methoxytetrabenazine ([11C]MTBZ), a high affinity radioligand for the vesicular monoamine transporter, has been examined in normal and tottering mice, which are neurological mutants. The tottering mice show significantly higher radiotracer accumulation (150-195% of controls) in all brain regions examined (striatum, cortex, hippocampus, hypothalamus, cerebellum and thalamus). The increases in [11C]MTBZ binding correlate (r = 0.91) with the reported increases in norepinephrine concentrations in these regions, and are consistent with the noradrenergic hyperinnervation characteristic of the tottering mutant mouse. These studies demonstrate that a mutant mouse model of increased innervation can be used to evaluate the sensitivity of an in vivo radiotracer measure, in this case [11C]MTBZ binding to vesicular transporters, to an increase in the numbers of binding sites in specific regions of the brain.

References

Oct 1, 1992·Brain Research. Molecular Brain Research·M C AustinJ N Crawley
Jan 1, 1992·Developmental Neuroscience·K R Isaacs, L C Abbott
Dec 1, 1991·Brain Research Bulletin·V K PatelG A Tejwani
Jul 1, 1990·Epilepsia·A E Dusser, S J Peroutka
Oct 1, 1990·Brain Research Bulletin·L C AbbottA S Hassan
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P Levitt, J L Noebels
Dec 1, 1993·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·J N DaSilvaT J Mangner
Apr 1, 1993·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·J N DaSilvaT J Mangner

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Citations

Mar 5, 2009·Molecular Neurobiology·Thomas S Guillot, Gary W Miller
Jun 10, 1998·Nuclear Medicine and Biology·W C Eckelman
Jan 20, 2007·The AAPS Journal·Guangrong ZhengPeter A Crooks
Jun 29, 2006·Home Health Care Services Quarterly·Scott Miyake Geron, Bronwyn Keefe
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S M Efange

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