Abstract
The pharmacokinetic-pharmacodynamic (PK/PD) modeling of enrofloxacin data using mutant prevention concentration (MPC) of enrofloxacin was conducted in febrile buffalo calves to optimize dosage regimen and to prevent the emergence of antimicrobial resistance. The serum peak concentration (Cmax ), terminal half-life (t1/2 K10) , apparent volume of distribution (Vd(area) /F), and mean residence time (MRT) of enrofloxacin were 1.40 ± 0.27 μg/mL, 7.96 ± 0.86 h, 7.74 ± 1.26 L/kg, and 11.57 ± 1.01 h, respectively, following drug administration at dosage 12 mg/kg by intramuscular route. The minimum inhibitory concentration (MIC), minimum bactericidal concentration, and MPC of enrofloxacin against Pasteurella multocida were 0.055, 0.060, and 1.45 μg/mL, respectively. Modeling of ex vivo growth inhibition data to the sigmoid Emax equation provided AUC24 h /MIC values to produce effects of bacteriostatic (33 h), bactericidal (39 h), and bacterial eradication (41 h). The estimated daily dosage of enrofloxacin in febrile buffalo calves was 3.5 and 8.4 mg/kg against P. multocida/pathogens having MIC90 ≤0.125 and 0.30 μg/mL, respectively, based on the determined AUC24 h /MIC values by modeling PK/PD data. The lipopolysaccharide-induced fever ...Continue Reading
References
Mar 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·Z L Zeng, K F Fung
Jun 1, 1986·The Journal of Antimicrobial Chemotherapy·U GanzingerE Schütze
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·J J SchentagI L Smith
Feb 1, 1985·Journal of Pharmaceutical Sciences·F C LamD G Perrier
Mar 1, 1982·Journal of Pharmaceutical Sciences·D Perrier, M Mayersohn
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·K K Chan, M Gibaldi
Mar 1, 1993·Research in Veterinary Science·K KüngM Wanner
May 1, 1993·Antimicrobial Agents and Chemotherapy·A ForrestJ J Schentag
Aug 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·M SprengH Drugeon
Oct 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·L KaartinenS Pyörälä
Feb 13, 2001·Antimicrobial Agents and Chemotherapy·J M BlondeauK Drlica
Feb 28, 2002·The Journal of Infectious Diseases·Xilin Zhao, Karl Drlica
Apr 30, 2002·International Journal of Antimicrobial Agents·D Andes, W A Craig
Jan 21, 2003·Emerging Infectious Diseases·Charles W Stratton
Jan 23, 2003·The Journal of Pharmacology and Experimental Therapeutics·Lynn O PostMichael J Myers
May 3, 2003·Research in Veterinary Science·F Shojaee Aliabadi, P Lees
Dec 23, 2003·The Journal of Antimicrobial Chemotherapy·Hans-Jörg Linde, Norbert Lehn
Nov 5, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·L Tollefson
Dec 17, 2004·Journal of Veterinary Pharmacology and Therapeutics·P L Toutain, P Lees
Mar 18, 2005·The Journal of Antimicrobial Chemotherapy·Johan W MoutonGeorge L Drusano
Jun 23, 2006·Biopharmaceutics & Drug Disposition·Anubha GuptaE Niclas Jonsson
Nov 4, 2006·The Journal of Infectious Diseases·Junchang CuiXilin Zhao
Nov 17, 2006·Research in Veterinary Science·D J DimitrovaB Pandova
Nov 23, 2006·Research in Veterinary Science·M Ismail, Y A El-Kattan
Aug 19, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara K Olofsson, Otto Cars
Aug 22, 2007·Antimicrobial Agents and Chemotherapy·Aude FerranAlain Bousquet-Mélou
Jul 16, 2008·International Journal of Antimicrobial Agents·Francesco Scaglione, Luca Paraboni
Jan 23, 2009·Journal of Clinical Microbiology·Xibiao TangHuanchun Chen
Nov 26, 2010·Journal of Veterinary Pharmacology and Therapeutics·P K SidhuP Lees
May 21, 2011·Journal of Medical Microbiology·Elias GebruSeung Chun Park
Aug 3, 2011·Antimicrobial Agents and Chemotherapy·Elisabet I NielsenLena E Friberg
Aug 15, 2013·Research in Veterinary Science·R M BalajeS Rampal