Mutant prevention concentrations of ciprofloxacin and enrofloxacin for Salmonella enterica

The Journal of Antimicrobial Chemotherapy
L P RandallMartin J Woodward

Abstract

To determine the mutant prevention concentrations (MPCs) of ciprofloxacin and enrofloxacin against four strains of Salmonella enterica serovar Enteritidis and four strains of S. Typhimurium including one fully susceptible, one multiply resistant (MAR), one GyrA mutant and one GyrA/MAR mutant. Further, to examine mutants arising after exposure to sub-MPC concentrations of the antibiotics for susceptibility to ciprofloxacin and enrofloxacin, and cyclohexane tolerance. MICs were determined using the agar dilution method of the BSAC. The MPC was recorded as the lowest concentration of antibiotic to inhibit growth from an inoculum of 10(10) cfu. The MPCs and resulting MPC/MIC ratios of enrofloxacin were generally two- to four-fold higher than for ciprofloxacin. At 24 h for both antibiotics, MPCs were lowest for the fully susceptible strains (0.25-0.5 mg/L), similar for the MAR (1-4 mg/L) and GyrA (2-4 mg/L) mutants and highest for the GyrA/MAR mutants (1-8 mg/L). MPC/MIC ratios at 24 h were 2-16 for all strains except those for the MAR strains without mutation in gyrA where the ratios were 8-64. The ability to eradicate Salmonella in vivo depends on many factors such as antibiotic susceptibility of the strain, dose and route of admi...Continue Reading

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Citations

Sep 28, 2010·Current Microbiology·Rafaela FerrariTereza Cristina Rocha Moreira Oliveira
May 16, 2009·Nature Reviews. Microbiology·Pamela J YehRoy Kishony
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jean-Baptiste MichelRoy Kishony
Dec 27, 2005·Antimicrobial Agents and Chemotherapy·Karl DrlicaChristine Hesje
Dec 19, 2015·The Journal of Antimicrobial Chemotherapy·Corinne N ThompsonStephen Baker
Nov 11, 2006·Médecine et maladies infectieuses·P Chavanet, D Croisier
Jan 24, 2006·International Journal of Antimicrobial Agents·Glen T HansenJoseph M Blondeau
Mar 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F Van BambekeP M Tulkens
May 26, 2005·The Journal of Antimicrobial Chemotherapy·A MurrayD J Brown

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