Mutation analysis of interleukin-5 in an asthmatic cohort

Human Mutation
E PereiraP Le Souëf

Abstract

Interleukin-5 (IL-5) is a potential candidate gene in the pathogenesis of asthma, as it is the main cytokine controlling eosinophil activity and eosinophils are pivotal in the development of airway inflammation. Mutation detection studies were performed on the IL-5 gene and the alpha-chain of its receptor in 30 asthmatic and 30 nonasthmatic subjects. Single-strand conformational polymorphism (SSCP) and heteroduplex analysis (HA) did not reveal any change from the reported normal sequence in all 4 exons of IL-5 as well as the promoter and 3'-untranslated regions of the gene. No SSCP variations were seen within the complete coding sequence of the IL-5 receptor alpha-chain. Mutations of the IL-5 gene coding region, its promoter and receptor are unlikely to be common causes of an inherited predisposition to asthma.

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Citations

Jul 17, 2008·Comparative and Functional Genomics·Maxim B FreidinValery P Puzyrev
Dec 7, 2007·The Journal of Allergy and Clinical Immunology·Kenji MatsumotoHirohisa Saito
May 17, 2000·Current Opinion in Pulmonary Medicine·M A Brown, M Halonen

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