Mutation analysis of the Sonic hedgehog promoter and putative enhancer elements in Parkinson's disease patients

Brain Research. Molecular Brain Research
Mads BakNiels Tommerup

Abstract

Sonic hedgehog (SHH) is involved in the induction and differentiation of nigrostriatale dopaminergic neurons. We have investigated the promoter, two putative enhancer elements and the coding region of SHH for mutations in patients with Parkinson's disease (PD). None of the identified sequence variations were present at a significantly different frequency in PD patients compared to healthy individuals, suggesting that they are not involved in the pathogenesis of PD.

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Citations

May 14, 2008·Experimental Cell Research·Morgan E CarlsonIrina M Conboy
Feb 23, 2012·Scientific Reports·André X C N ValenteYuan Gao

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