PMID: 15244246Jul 13, 2004Paper

Mutation and accumulation of p53 related to results of adjuvant therapy of postmenopausal breast cancer patients

Acta Oncologica
Marie Stenmark AskmalmOlle Stål

Abstract

p53 protein accumulation and gene mutation have been implicated in resistance to cytotoxic treatment. This study was performed to further assess the predictive value of p53 in breast cancer. Postmenopausal patients were randomized to adjuvant chemotherapy with cyclophosphamide, metothrexate, or 5-fluorouracil (CMF) vs. postoperative radiotherapy. The patients were also randomized to adjuvant tamoxifen vs. no endocrine treatment. Immunohistochemistry (IHC) and single-strand conformation polymorphism (SSCP), followed by direct sequencing, was performed. The p53 altered group, regarded as positive for p53 gene mutation and/or p53 protein accumulation, tended to benefit more from CMF than from radiotherapy as compared with others regarding distant recurrences. In the group lacking p53 alteration there was a significantly decreased local recurrence rate in the radiotherapy group as compared with the CMF group (RR = 0.24, 95% CI = 0.083 0.62), whereas no benefit from radiotherapy was found for patients showing p53 alterations. Tamoxifen significantly decreased the rate of distant recurrence for estrogen receptor-positive patients with no apparent difference in relation to p53 alteration. It is suggested that p53 alteration indicates ...Continue Reading

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Citations

Nov 3, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A P B BatschauerM G Carvalho
Jul 12, 2005·The Breast : Official Journal of the European Society of Mastology·Eeva RahkoArja Jukkola
Apr 13, 2006·Pharmacogenetics and Genomics·Pia WegmanSten Wingren
Oct 19, 2010·Breast Cancer Research and Treatment·Gizeh Pérez-TenorioOlle Stål
May 14, 2016·Oncotarget·Cynthia VeenstraOlle Stål

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