Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists

Molecular and Cellular Biology
M S DionneR M Harland


The Dan family of transforming growth factor beta antagonists is a large, evolutionarily conserved family of proteins. Little is known about either the specificity of these antagonists or the biological roles of these proteins. We have characterized Dan, the founding member of this family, with regard to both its biochemical specificity and its biological roles. Although DAN is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo. Intriguingly, in developing neurons, Dan mRNA was localized to axons, suggesting a potential role for the DAN protein in axonal outgrowth or guidance. Mice lacking Dan activity were generated by gene targeting and displayed subtle, background-dependent defects.


Aug 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J J Bieker, M Yazdani-Buicky
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E A WangJ M Wozney
Jan 1, 1995·Developmental Genetics·A Hemmati-Brivanlou, G H Thomsen
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·W C SkarnesR S Beddington
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T Ozaki, S Sakiyama
Jul 31, 1998·Science·A ColavitaJ G Culotti
Nov 30, 1998·Mechanisms of Development·E StanleyR P Harvey
Mar 12, 1999·Mechanisms of Development·H NeuhausR S Thies
Apr 20, 1999·Developmental Biology·J J PearceJ Rossant
Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L Dale, C M Jones

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