Mutation breeding of lycopene-producing strain Blakeslea trispora by a novel atmospheric and room temperature plasma (ARTP)

Applied Biochemistry and Biotechnology
Wang QiangYu Xiao-bin

Abstract

To improve the fermentation efficiency of lycopene, a plasma jet, driven by an active helium atom supplied with atmospheric and room temperature plasma (ARTP) biological breeding system, was used as a new method to generate mutations in Blakeslea trispora (-). After several rounds of screening, a mutant A5 with high concentration of lycopene and dry biomass was isolated, which showed a maximum lycopene concentration (26.4 ± 0.2 mg/g dry biomass) which was 55 % higher than the parent strain (16.9 ± 0.3 mg/g dry biomass) in the production of lycopene. Compared with parent strain, B. trispora A5 required less dissolved oxygen (10 % less than that of parent strain) to reach maximum concentration in a 5-L stirred tank reactor batch fermentation.

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Citations

Oct 16, 2015·Preparative Biochemistry & Biotechnology·Gong ChengWeiguo Zhang
Oct 26, 2016·Journal of Bioscience and Bioengineering·Yanlong WangDefu Chen
Jan 10, 2018·Bioprocess and Biosystems Engineering·Jiali XuHe Huang
Jan 11, 2020·Applied Microbiology and Biotechnology·Qinghui YuGuoquan Hu
Jan 19, 2020·Applied and Environmental Microbiology·Wei LuoXiaobin Yu
Aug 31, 2018·Biotechnology for Biofuels·Jin JinYingjin Yuan
Nov 1, 2016·Bioscience, Biotechnology, and Biochemistry·Tingting QinHe Huang
Feb 26, 2019·Bioprocess and Biosystems Engineering·Weimeng FengJianhua Chen
Jun 1, 2020·Applied Microbiology and Biotechnology·KaiYue LiuWenJing Sun
Oct 25, 2020·Applied Microbiology and Biotechnology·Lei LiXiangzhao Mao

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