Mutation Frequencies in Endometrial Cancer Patients of Different Ethnicities and Tumor Grades: An Analytical Study

Saudi Journal of Medicine & Medical Sciences
Mohammad A Althubiti

Abstract

Endometrial carcinoma is a predominant health problem for women worldwide. However, there is a lack of data on genetic mutation frequencies in endometrial cancer patients of different ethnicities and tumor grades. The objective of this study is to provide data regarding mutation frequencies in endometrial cancer patients of different ethnic groups and tumor grades by analyzing large-scale cancer genomic datasets of a database. The following databases of cBioPortal were explored for possible mutation frequency variations in endometrial cancer patients: the Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) database for ethnicity-based studies; the Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) database for tumor grade-based study; and GDC Data Portal database for calculating survival rates using the Kaplan-Meier method. PTEN mutation frequency was almost identical in all ethnic groups studied (White, Black/African American, Asian, Native Hawaiian or other Pacific Islander, and American Indian or Asian Native). PIK3CA and ARID1A mutation frequencies were higher in White and Asian patients compared with other ethnicities; TP53 and FAT1 mutation frequencies were higher in Black/African Americans; and CTNNB1 and ...Continue Reading

Citations

Mar 19, 2020·Cancers·Li ZhangSamuel C Mok
Sep 30, 2020·Journal of Clinical Medicine·Piotr K ZakrzewskiWanda M Krajewska
Jul 12, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yusuke KogaFranklin W Huang
Jun 3, 2021·Cancers·Iram FatimaVishal Chandra
Jul 2, 2021·Cell Reports Medicine·Soulaimane AboulouardMichel Salzet

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