PMID: 6991876Apr 1, 1980Paper

Mutation frequency decline in a rel strain of E. coli coli B/r

Molecular & General Genetics : MGG
J Engstrom, R Bockrath

Abstract

Mutation frequency decline (MFD) occurs among certain suppressor mutations induced by UV irradiation of E. coli. When irradiated bacteria are incubated in conditions less than optimal for protein synthesis prior to plating, a large majority of the potential mutants are rapidly lost. For several years the belief has existed that MFD results because stringent control of transcription at tRNA genes may influence excision repair of premutational photoproducts at these sites. We have constructed a rel mutant of E. coli B/r strain WU3610, verified that it has a typical phenotype of a relaxed strain in terms of RNA and ppGpp synthesis, and measured MFD. The kinetics of MFD were the same in WU3610 and WU3610 rel. Thus stringent control is not essential to MFD and there is no reason to believe that moderation of transcription at tRNA genes is integral to the MFD mechanism.

References

Jan 1, 1977·Cell·P Edelmann, J Gallant
Nov 14, 1977·Molecular & General Genetics : MGG·R C Bockrath, J E Palmer
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T V Ramabhadran, J Jagger
Feb 1, 1972·Physiology & Behavior·T J TeylerR F Thompson
Jan 1, 1969·Annual Review of Microbiology·E M Witkin
Jan 1, 1956·Cold Spring Harbor Symposia on Quantitative Biology·E M WITKIN
Dec 15, 1961·Proceedings of the National Academy of Sciences of the United States of America·G S STENT, S BRENNER
Mar 26, 1963·Biochimica Et Biophysica Acta·F C NEIDHARDT, L EIDLIC
May 1, 1958·Proceedings of the National Academy of Sciences of the United States of America·C O Doudney, F L Haas

❮ Previous
Next ❯

Citations

Jun 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E M Witkin
Dec 1, 1993·Journal of Bacteriology·C P Selby, A Sancar
Sep 1, 1994·Microbiological Reviews·C P Selby, A Sancar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.