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Mutation in blood coagulation factor V associated with resistance to activated protein C

Nature

May 5, 1994

R M BertinaP H Reitsma

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Abstract

Activated protein C (APC) is a serine protease with potent anticoagulant properties, which is formed in blood on the endothelium from an inactive precursor. During normal haemostasis, APC limits clot formation by proteolytic inactivation of factors Va and VIIIa (ref. 2). To do this effi...read more

Mentioned in this Paper

Deep Vein Thrombosis of Lower Limb
Protein C, human
Factor V
Deep Vein Thrombosis
Venous Thrombosis
Protein C Measurement
Thrombophilia DUE TO Activated Protein C Resistance (Disorder)
Proteolytic Enzyme
Blood Coagulation Disorders
Protein C Antigen Measurement
4
252
2
Paper Details
References
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  • Citations1768
12
  • References17
  • Citations1768
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Mutation in blood coagulation factor V associated with resistance to activated protein C

Nature

May 5, 1994

R M BertinaP H Reitsma

PMID: 8164741

DOI: 10.1038/369064a0

Abstract

Activated protein C (APC) is a serine protease with potent anticoagulant properties, which is formed in blood on the endothelium from an inactive precursor. During normal haemostasis, APC limits clot formation by proteolytic inactivation of factors Va and VIIIa (ref. 2). To do this effi...read more

Mentioned in this Paper

Deep Vein Thrombosis of Lower Limb
Protein C, human
Factor V
Deep Vein Thrombosis
Venous Thrombosis
Protein C Measurement
Thrombophilia DUE TO Activated Protein C Resistance (Disorder)
Proteolytic Enzyme
Blood Coagulation Disorders
Protein C Antigen Measurement
4
252
2

Feeds With Similar Papers

Thrombosis and Hemostasis

Thrombosis, the formation of a blood clot inside a blood vessel that obstructs the flow of blood through the circulatory system, is thought to occur when natural hemostatic mechanisms, which help restrict the clot to the site of injury, are genetically impaired or are overwhelmed by the severity of the initial injury. Discover the latest research on hemostasis and thrombosis here.

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Related Papers

Paper Details
References
  • References17
  • Citations1768
12
  • References17
  • Citations1768
12345...

Download from

Publisher
PubMed
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