Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes

Proceedings of the National Academy of Sciences of the United States of America
P MulsantJean Michel Elsen

Abstract

Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation rate and litter size. This phenotype is due to the action of the FecB(B) allele of a major gene named FecB, as determined by statistical analysis of phenotypic data. By genetic analysis of 31 informative half-sib families from heterozygous sires, we showed that the FecB locus is situated in the region of ovine chromosome 6 corresponding to the human chromosome 4q22-23 that contains the bone morphogenetic protein receptor IB (BMPR-IB) gene encoding a member of the transforming growth factor-beta (TGF-beta) receptor family. A nonconservative substitution (Q249R) in the BMPR-IB coding sequence was found to be associated fully with the hyperprolificacy phenotype of Booroola ewes. In vitro, ovarian granulosa cells from FecB(B)/FecB(B) ewes were less responsive than granulosa cells from FecB(+)/FecB(+) ewes to the inhibitory effect on steroidogenesis of GDF-5 and BMP-4, natural ligands of BMPR-IB. It is suggested that in FecB(B)/FecB(B) ewes, BMPR-IB would be inactivated partially, leading to an advanced differentiation of granulosa cells and an advanced maturation of ovulatory follicles.

References

Jan 1, 1987·Journal of Steroid Biochemistry·K P McNatty, K M Henderson
Nov 25, 1988·Nucleic Acids Research·F Corpet
Jan 1, 1985·Journal of Reproduction and Fertility·M A DriancourtB M Bindon
Jul 1, 1994·Genomics·G W MontgomeryA M Crawford
Jan 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·I LannelucJ Gellin
Jan 1, 1996·Cytogenetics and Cell Genetics·I LannelucJ M Elsen
Jul 1, 1997·The EMBO Journal·Y G ChenJ Massague
Feb 11, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L SchiblerE P Cribiu
Aug 28, 1998·Cytokine & Growth Factor Reviews·M KawabataK Miyazono
May 26, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D VaimanE P Cribiu
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·S ShimasakiG F Erickson
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·J AaltonenO Ritvos

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Citations

Oct 7, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Eveline M Ibeagha-AwemuXin Zhao
Aug 9, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Aurélie VinetFlorence Phocas
Jun 14, 2005·Domestic Animal Endocrinology·Morag G HunterCheryl J Ashworth
Dec 6, 2003·Molecular and Cellular Endocrinology·N di ClementeC Belville
Dec 6, 2003·Molecular and Cellular Endocrinology·Peter ten DijkeMarie-José Goumans
Apr 20, 2005·Molecular and Cellular Endocrinology·K P McNattyJ L Juengel
Apr 20, 2005·Molecular and Cellular Endocrinology·R Kelly Moore, Shunichi Shimasaki
Jun 5, 2002·Molecular and Cellular Endocrinology·S M GallowayG H Davis
Jun 24, 2003·Animal Reproduction Science·Philip G Knight, Claire Glister
Jun 24, 2003·Animal Reproduction Science·A C O Evans
Jul 27, 2002·Domestic Animal Endocrinology·Philippe MongetDanielle Monniaux
Feb 20, 2003·Trends in Endocrinology and Metabolism : TEM·Nathalie Josso, Nathalie di Clemente
Jul 28, 2011·Zygote : the Biology of Gametes and Early Embryos·Ma Ninia L GomezByeong Chun Lee
Jan 1, 2009·Animal : an International Journal of Animal Bioscience·P LaissueD Vaiman
Mar 24, 2011·Reproduction, Fertility, and Development·R J ScaramuzziR Webb
Aug 30, 2011·Reproduction, Fertility, and Development·K J DemmersJ L Juengel
Jan 28, 2012·Reproduction, Fertility, and Development·Karen L ReaderKenneth P McNatty
Jul 22, 2011·Animal Biotechnology·Joyabrata RoySurender Lal Goswami
Aug 13, 2010·Biology of Reproduction·Koji SugiuraJohn J Eppig
Feb 16, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suzannah A Williams, Pamela Stanley
Oct 9, 2002·Clinical Obstetrics and Gynecology·Trevor WoodageSamuel Broder
Apr 14, 2006·Reproductive Biology and Endocrinology : RB&E·Stéphane FabreDanielle Monniaux
Oct 31, 2009·Endocrine Journal·Fumio Otsuka
Sep 29, 2011·Yi chuan = Hereditas·Jian-Qi Wang, Wen-Guang Cao
Mar 27, 2007·International Journal of Biological Sciences·Kefei ChenLawrence B Schook
Aug 29, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Linda NicolAlan S McNeilly

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