PMID: 9529064Apr 7, 1998Paper

Mutation of invH, but not stn, reduces Salmonella-induced enteritis in cattle

Infection and Immunity
P R WatsonT S Wallis

Abstract

The induction of secretory and inflammatory responses in calves by Salmonella typhimurium and Salmonella dublin strains was compared, and the effects of mutations in the invH and stn genes were assessed. S. typhimurium induced greater secretory and inflammatory responses than S. dublin in bovine ileal loops, despite the fact that these serotypes were recovered from bovine ileal mucosa in comparable numbers (P. R. Watson, S. M. Paulin, A. P. Bland, P. W. Jones, and T. S. Wallis, Infect. Immun. 63:2743-2754, 1995). These results implicate serotype-specific factors other than, or in addition to, intestinal invasion in the induction of enteritis. The secretory and inflammatory responses induced by S. typhimurium and S. dublin in bovine ligated ileal loops were not significantly altered by mutation of stn, which suggests that stn does not have a major role in Salmonella-induced enteritis. The invH mutation significantly reduced the secretory and inflammatory responses induced in bovine ileal loops, and this correlated with a reduction in the severity of enteritis following oral inoculation of calves. The attenuation associated with the invH mutation did not appear to be due to an increased susceptibility to the innate host defense m...Continue Reading

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Citations

Nov 4, 2004·Molecular Microbiology·Eirwen MorganTimothy S Wallis
Aug 19, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark P StevensDuncan J Maskell
Jun 26, 2014·Journal of Veterinary Science·Li-Ming WuDing-Zong Guo
Mar 25, 2015·PLoS Neglected Tropical Diseases·Chinyere K OkoroRobert A Kingsley
Nov 13, 2015·PLoS Pathogens·Shabarinath SrikumarJay C D Hinton
Jan 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R L SantosL G Adams
May 31, 2001·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M A UnmackE Skadhauge
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·C A LeeB A McCormick
Dec 24, 2002·Infection and Immunity·Shuping ZhangAndreas J Bäumler
Dec 6, 2006·Immunology and Cell Biology·Bryan CoburnB B Finlay
Mar 12, 2013·Nature Reviews. Microbiology·Bärbel StecherWolf-Dietrich Hardt
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MiroldW D Hardt
Feb 13, 2001·Annual Review of Medicine·M E Ohl, S I Miller
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siegfried HapfelmeierWolf-Dietrich Hardt
Jul 4, 2007·Expert Reviews in Molecular Medicine·Abigail N Layton, Edouard E Galyov
Apr 14, 2010·Infection and Immunity·Helene L Andrews-PolymenisFerric C Fang
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·F A NorrisP W Majerus
May 16, 2007·Antimicrobial Agents and Chemotherapy·Debra L HudsonEdouard E Galyov

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