PMID: 9185741Jun 1, 1997Paper

Mutation of p53 in squamous cell cancer of the head and neck: relationship to tumor cell proliferation

The Laryngoscope
N B WoodJ S Coon

Abstract

Rapid proliferation of squamous cell carcinomas of the head and neck (SCCHN) during therapy may contribute to treatment failure. We have investigated the presence of p53 abnormalities in patients with SCCHN as a correlate of proliferation rate and other pathologic and clinical variables. p53 Mutation, as determined by polymerase chain reaction and single-strand conformation polymorphism analysis of microdissected frozen sections of tumor biopsies, was significantly associated with a high labeling index, as determined by in vivo infusion of IUdR and BrdU (P = 0.017). p53 Protein expression was detected by immunohistochemistry with two different antibodies, followed by quantitative image analysis. Many cases exhibited strong p53 protein expression in the absence of mutations within the conserved region of the gene, and expression was not related to proliferation. The presence of p53 mutations was related to tumor differentiation in this group of patients.

References

Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G GaidanoR Dalla-Favera
Jun 1, 1994·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·L XuP Garin-Chesa
Aug 15, 1987·Applied Optics·J W Bacus, L J Grace

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Citations

Nov 7, 2001·The American Journal of Pathology·S L HolleyP R Hoban
May 20, 1998·The Laryngoscope·L C WhislerJ S Coon
Oct 21, 2000·Molecular Pathology : MP·H K Williams
Jan 16, 2004·Head & Neck·Juan Carlos de VicenteJuan Sebastián López Arranz
Aug 30, 2003·Oncogene·Bruce G Haffty, Peter M Glazer

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