Mutation of the 5' noncoding region of the BCL-6 gene in low-grade gastric lymphoma of the mucosa-associated lymphoid tissue

Cancer Genetics and Cytogenetics
R LiangG Srivastava

Abstract

BCL-6 gene rearrangement and hypermutations were investigated in four Hong Kong Chinese patients with low-grade gastric lymphoma of the mucosa-associated lymphoid tissue (MALToma). The former was studied by Southern analysis and the latter by the technique of polymerase chain reaction and denaturing gradient gel electrophoresis. BCL-6 gene rearrangement was not detectable in any of the four cases. However, mutations at both the E1.11 and E1.12 segments of the 5' noncoding region of the BCL-6 gene were found in two patients. This preliminary observation suggests that the mutations of the 5' noncoding region of the BCL-6 gene rather than gene rearrangement may be playing a more important role in the tumorigenesis of low-grade gastric MALToma. Further confirmation of this finding by studying a larger number of patients will be required.

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Citations

Nov 24, 1999·Cancer Genetics and Cytogenetics·Y S FanJ Engel
Nov 12, 1998·The American Journal of Pathology·H K Müller-Hermelink, A Greiner
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Oct 3, 1999·Current Opinion in Oncology·A Sarris, R Ford
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