Abstract
Although a wide number of breast cancer susceptibility alleles associated with various levels of risk have been identified to date, about 50% of the heritability is still missing. Although the major BRCA1 and BRCA2 genes are being extensively screened for truncating and missense variants in breast and/or ovarian cancer families, potential regulatory variants affecting their expression remain largely unexplored. In an attempt to identify such variants, we focused our attention on gene regulation mediated by microRNAs (miRs). We screened two genes, MIR146A and MIR146B, producing miR-146a and miR-146b-5p, respectively, that regulate BRCA1, and the 3'- untranslated regions (3'-UTRs) of BRCA1 and BRCA2 in the GENESIS French national case/control study (BRCA1- and BRCA2-negative breast cancer cases with at least one sister with breast cancer and matched controls). We identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls. Among these 11 rare variants, 7 were identified each in 1 index case. None of the three relevant MIR146A/MIR146B variants affected the pre-miR sequences. The potential causality of the four relevant BRCA1/BRCA2 3'-UTRs variants was ev...Continue Reading
References
Apr 17, 1998·JAMA : the Journal of the American Medical Association·B NewmanM C King
May 27, 2005·Journal of Cancer Research and Clinical Oncology·Andrea PietschmannHartmut Peters
Oct 15, 2005·Science·Jesse F AbelsonMatthew W State
Jun 6, 2006·Nature Genetics·Alex ClopMichel Georges
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Jul 29, 2008·Carcinogenesis·Jie ShenHua Zhao
May 2, 2009·Genetic Testing and Molecular Biomarkers·Malinee PongsaveePimpicha Patmasiriwat
Jul 2, 2009·PloS One·Jinong FengSteve S Sommer
Jun 15, 2010·Molecular Oncology·Nasim MavaddatMontserrat Garcia-Closas
Sep 18, 2010·Breast Cancer Research and Treatment·Stéphanie LheureuxAgnès Hardouin
Dec 31, 2010·Cell Cycle·Cory PelletierJoanne B Weidhaas
Apr 8, 2011·EMBO Molecular Medicine·Amandine I GarciaSylvie Mazoyer
Jul 4, 2012·Human Mutation·Brooke L BrewsterPaolo Peterlongo
Jan 15, 2013·Current Opinion in Cell Biology·Matthew T Blahna, Akiko Hata
Nov 19, 2013·Human Genetics·A WojcickaK Jazdzewski
Jun 10, 2014·Oncogene·X ChenF J Slack
Jun 18, 2014·PloS One·Juliana GiacomazziPatricia Ashton-Prolla
Aug 20, 2014·Current Biology : CB·Brian D AdamsFrank J Slack
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Elif ErturkIsmet Tasdelen
Nov 13, 2014·PloS One·Sofia KhanHeli Nevanlinna
Nov 25, 2014·Oncogene·E KumaraswamyR A Jensen
Dec 4, 2014·Cancer Treatment Reviews·P EconomopoulouA Psyrri
Mar 10, 2015·Nature Genetics·Kyriaki MichailidouDouglas F Easton
Mar 15, 2015·Human Molecular Genetics·Marina DuslAngela Abicht
Sep 5, 2015·Public Health Genomics·Zorana Z NikolićGoran N Brajušković
Nov 21, 2015·Journal of the National Cancer Institute·Huong D MeeksDavid E Goldgar
Jan 14, 2016·BMC Cancer·Olga M SinilnikovaNadine Andrieu
Citations
Jan 18, 2018·The British Journal of Surgery·P McAnenaM J Kerin
Dec 14, 2017·Breast Cancer Research and Treatment·E Santana Dos SantosE Rouleau
Nov 21, 2018·Cancers·Elizabeth Santana Dos SantosEtienne Rouleau
May 18, 2020·Diagnostics·María Marisela Sánchez-ChaparroIram Pablo Rodríguez-Sánchez