Mutation-selection balance for environmental variance

The American Naturalist
Xu-Sheng Zhang, William G Hill

Abstract

The role of mutation-selection balance in maintaining environmental variance (V(E)) of quantitative traits is investigated under the assumption that genotypes differ in the magnitude of phenotypic variance, given genotypic value. Thus, V(E) can be regarded as a quantitative trait. As stabilizing selection on phenotype favors genotypes contributing low V(E), mutations that decrease V(E) are more likely to become fixed than those that increase it, and therefore V(E) should decline. If, however, essentially all mutants increase V(E) and overall selection is sufficiently strong that no mutants become fixed, then V(E) can be maintained. The heritability of the trait is determined by the relative sizes of mutational effects on phenotypic mean and residual variance and is independent of mutation rate and pleiotropic effects. This conclusion is not robust for small populations because some mutants may become fixed, which indicates that other selective forces must be involved, such as an intrinsic cost of homogeneity.

References

Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·W G Hill
Aug 20, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Trudy F Mackay, Richard F Lyman
May 17, 2006·Trends in Ecology & Evolution·Xu-Sheng Zhang, William G Hill
Jun 30, 2007·Evolution; International Journal of Organic Evolution·Xu-Sheng Zhang, William G Hill
Aug 19, 2008·The American Naturalist·J G KingsolverP Beerli

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Citations

Dec 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William G Hill
Mar 25, 2011·Genetics Research·William G Hill, Han A Mulder
Apr 30, 2010·Behavior Genetics·Peter M Visscher, Danielle Posthuma
Jan 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Justin B LackJohn E Pool
Oct 20, 2009·Theoretical Population Biology·Xu-Sheng Zhang, William G Hill
Jun 8, 2015·BMC Evolutionary Biology·Eleonore DurandChristine Dillmann
Jul 10, 2018·Evolution; International Journal of Organic Evolution·Benjamin R GrothJohn E Pool
May 7, 2015·Scientific Reports·Fabio MorganteTrudy F C Mackay
Aug 28, 2020·G3 : Genes - Genomes - Genetics·Christopher Kozela, Mark O Johnston
May 23, 2018·Seminars in Cell & Developmental Biology·Mark Webster

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