Abstract
Epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) are a relatively new class of drugs for treatment of non-small-cell lung cancer. The national professional group for lung cancer, The Norwegian Lung Cancer Group, recommends that patients with non-small-cell lung cancer are tested for mutations in the EGFR gene. Here, we report the experience collected after the introduction of such testing in Norway in 2010. Information on the number of patients tested, gender distribution, histopathological data and analysis results have been collected from the molecular-pathology laboratories at the university hospitals in Tromsø, Trondheim, Bergen and Oslo for the period from May 2010 to May 2011. During this period, altogether 1,058 patients with lung cancer were tested for mutations in the EGFR gene, equal to approximately half of all those who were diagnosed with non-small-cell lung cancer. A mutation was detected in 123 patients (11.6 per cent). There was a higher proportion of mutation-positive women than men (17.6 per cent, compared to 6.3 per cent, p < 0.001), and a lower proportion with squamous cell carcinoma than for other histopathological subtypes (3.0 per cent, compared to 12.9 per cent, p < 0.001). O...Continue Reading
References
Aug 29, 2000·Journal of Clinical Pathology·S L EdwardsK M Kerr
May 1, 2004·The New England Journal of Medicine·Thomas J LynchDaniel A Haber
May 1, 2004·Science·J Guillermo PaezMatthew Meyerson
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Jul 15, 2005·The New England Journal of Medicine·Ming-Sound TsaoFrances A Shepherd
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
Jun 28, 2007·British Journal of Cancer·N HelbekkmoUNKNOWN Norwegian Lung Cancer Study Group
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Aug 21, 2009·The New England Journal of Medicine·Adi F Gazdar
Aug 21, 2009·The New England Journal of Medicine·Rafael RosellUNKNOWN Spanish Lung Cancer Group
Dec 10, 2009·Seminars in Oncology·David PlanchardJean-Charles Soria
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Sep 28, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Robert PirkerUNKNOWN European EGFR Workshop Group
Jan 5, 2011·Thorax·Camilla M T SagerupOdd Terje Brustugun
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Åslaug HellandOdd Terje Brustugun
Jul 26, 2011·The Lancet Oncology·Caicun ZhouChangxuan You
Citations
Aug 28, 2015·Acta Oncologica·Janna BergÅslaug Helland
Nov 7, 2015·The European Respiratory Journal·Y NilssenB Møller
Mar 12, 2015·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Odd Terje Brustugun
Jul 24, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Odd Terje BrustugunSteinar Kristian Solberg