Mutation trend of hemagglutinin of influenza A virus: a review from a computational mutation viewpoint.

Acta Pharmacologica Sinica
Guang Wu, Shao-Min Yan

Abstract

Since 1999 we have developed two computational mutation approaches to analyze the protein primary structure whose methodology and implications were reviewed in 2002. Our first approach is the calculation of predictable and unpredictable portions of amino-acid pairs in a protein, and the second is the calculation of amino-acid distribution rank in a protein. Both approaches provide quantitative measures to present a protein, which we have used to study a number of proteins with numerous mutations such as p53 proteins. More recently, we focussed our efforts on analyzing the proteins mutating frequently over time such as hemagglutinins of influenza A viruses. In this review we summarise our findings and their implications for hemagglutinin mutations in combination with some newly available data. Our approaches throw light on the true nature of genetic heterogeneity of influenza virus hemagglutinins; that is, the protein variability is highly relevant to its amino-acid construction. Using these approaches, we can monitor new mutations from influenza virus hemagglutinins and may predict their mutations in the future.

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Citations

Jan 25, 2013·Applied Biochemistry and Biotechnology·Shaomin Yan, Guang Wu
Jul 20, 2010·Interdisciplinary Sciences, Computational Life Sciences·Shao-Min Yan, Guang Wu
Jul 20, 2010·Interdisciplinary Sciences, Computational Life Sciences·Shao-Min Yan, Guang Wu
May 5, 2011·Interdisciplinary Sciences, Computational Life Sciences·Shao-Min Yan, Guang Wu
Mar 7, 2012·Interdisciplinary Sciences, Computational Life Sciences·Shao-Min YanGuang Wu
Jan 16, 2010·Computer Methods in Biomechanics and Biomedical Engineering·Shaomin Yan, Guang Wu
Sep 6, 2008·Journal of Clinical Monitoring and Computing·Shaomin Yan, Guang Wu
Jan 1, 2008·Influenza and Other Respiratory Viruses·Michael E BoseKelly J Henrickson
Jun 14, 2014·Veterinary Microbiology·Guadalupe López-RoblesJesús Hernández
May 27, 2009·Molecular Diversity·Shaomin Yan, Guang Wu

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