Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats

Japanese Journal of Cancer Research : Gann
H Sakai, K Ogawa

Abstract

We examined mutational activation of H- and K-ras genes in hyperplastic nodules and hepatocellular carcinomas induced by N-nitroso-N-methylurea or diethylnitrosamine using the polymerase chain reaction, followed by dot-blot hybridization. No mutational activation was detected in these hepatic lesions. The results indicate that low incidence of the activation of H- and K-ras genes in rat liver tumors is due to the organ specificity rather than the nature of the carcinogens used.

References

Mar 1, 1989·Japanese Journal of Cancer Research : Gann·H TsudaM Terada
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May 1, 1986·Molecular and Cellular Biology·M RutaE M Scolnick
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Citations

Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·R OstermayrH M Rabes
Dec 1, 1994·Environmental Health Perspectives·G McMahon
Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·H Sakai, K Ogawa
Jan 11, 2000·International Journal of Cancer. Journal International Du Cancer·S Boivin-AngèleM J Marion
Jan 1, 1991·Molecular Carcinogenesis·H OhgakiG C Hard
Jan 1, 1991·Comparative Immunology, Microbiology and Infectious Diseases·L Z Xu, D Larzul

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Methods Mentioned

BETA
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