Mutational analysis of caspase 1, 4, and 5 genes in common human cancers

Human Pathology
Young Hwa SoungSug Hyung Lee

Abstract

Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Mutations of genes encoding caspases, the executioners of apoptosis, have been detected in human cancers, indicating inactivation of apoptosis by the mutations of caspase is an important mechanism in cancer development. The aim of this study was to see whether genes encoding human caspases 1, 4, and 5 are mutated in human cancers. We analyzed the entire coding region and all splice sites of human caspase 1, 4, and 5 genes for the detection of somatic mutations in 337 human cancers, including 103 colorectal, 54 gastric, 60 breast, 60 hepatocellular, and 60 lung carcinomas by a single-strand conformation polymorphism assay. We detected 2 (0.6%) caspase-1, 2 (0.6%) caspase-4, and 15 (4.4%) caspase-5 mutations in the 343 cancers. The mutations were detected in 11 gastric carcinomas (2 caspase-1 and 9 caspase-5 mutations), 6 colorectal carcinomas (2 caspase-4 and 4 caspase-5 mutations), 1 breast carcinoma (1 caspase-5 mutation), and 1 lung carcinoma (1 caspase-5 mutation). The mutations consisted of 11 mutations in exons and 8 mutations in noncoding sequences. The 11 mutations in the exons consisted of 3 missense, 1 silent...Continue Reading

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Citations

Jun 28, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R D MittalA Mandhani
Sep 19, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M S KimN J Yoo
Apr 21, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Min Sung KimSug Hyung Lee
Jul 19, 2011·The American Journal of Pathology·Dorian R A SwartsErnst-Jan M Speel
May 6, 2014·Frontiers in Physiology·Patrick F ConnollyHoward O Fearnhead
Nov 6, 2018·Scientific Reports·Xuguo Zhu, Shuangqi Li
May 30, 2020·International Journal of Molecular Sciences·Christian Sordo-BahamondeAlejandro López-Soto
Jul 25, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiasi WuXianli Meng
Jul 21, 2017·Biochemistry·Kevin B DagbayJeanne A Hardy

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