Abstract
Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Mutations of genes encoding caspases, the executioners of apoptosis, have been detected in human cancers, indicating inactivation of apoptosis by the mutations of caspase is an important mechanism in cancer development. The aim of this study was to see whether genes encoding human caspases 1, 4, and 5 are mutated in human cancers. We analyzed the entire coding region and all splice sites of human caspase 1, 4, and 5 genes for the detection of somatic mutations in 337 human cancers, including 103 colorectal, 54 gastric, 60 breast, 60 hepatocellular, and 60 lung carcinomas by a single-strand conformation polymorphism assay. We detected 2 (0.6%) caspase-1, 2 (0.6%) caspase-4, and 15 (4.4%) caspase-5 mutations in the 343 cancers. The mutations were detected in 11 gastric carcinomas (2 caspase-1 and 9 caspase-5 mutations), 6 colorectal carcinomas (2 caspase-4 and 4 caspase-5 mutations), 1 breast carcinoma (1 caspase-5 mutation), and 1 lung carcinoma (1 caspase-5 mutation). The mutations consisted of 11 mutations in exons and 8 mutations in noncoding sequences. The 11 mutations in the exons consisted of 3 missense, 1 silent...Continue Reading
References
Sep 1, 1992·Human Genetics·M KrawczakD N Cooper
Apr 30, 1992·Nature·N A ThornberryJ Aunins
Jun 23, 1995·The Journal of Biological Chemistry·J KamensP Li
Jun 30, 1995·The Journal of Biological Chemistry·N A MundayD W Nicholson
Feb 7, 1997·Cell·S Nagata
Aug 29, 1997·The Journal of Experimental Medicine·S MandruzzatoP van der Bruggen
Jul 3, 1999·Oncogene·S H LeeN J Yoo
Dec 1, 1999·Cell Death and Differentiation·D W Nicholson
Dec 1, 1999·Cell Death and Differentiation·S Kumar
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Nov 14, 2000·The American Journal of Pathology·J C Reed
Jul 4, 2001·The Journal of Biological Chemistry·S H LeeJ C Reed
May 16, 2002·Blood·Min Sun ShinSug Hyung Lee
Sep 2, 2003·Gastroenterology·Hong Sug KimSug Hyung Lee
Sep 10, 2003·International Journal of Molecular Medicine·Y HosomiS Kudoh
Sep 13, 2003·Oncogene·Young Hwa SoungSug Hyung Lee
May 1, 1954·Cancer·H A EDMONDSON, P E STEINER
Mar 3, 2004·Nature Reviews. Cancer·P Andrew FutrealMichael R Stratton
May 28, 2004·Cell·Fabio Martinon, Jürg Tschopp
Sep 24, 2004·Cancer Cell·Bharat B Aggarwal
May 12, 2005·Molecular Cancer Research : MCR·Judith OffmanPeter Karran
May 13, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Young Hwa SoungSug Hyung Lee
Sep 5, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jong Woo LeeSug Hyung Lee
Citations
Aug 29, 2012·The Journal of Biological Chemistry·Wei Bin FangNikki Cheng
Jul 16, 2009·PloS One·Linda M DongLee E Moore
Feb 4, 2014·PloS One·Feng ZhaoWei Zhang
Jun 28, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R D MittalA Mandhani
Mar 10, 2009·Human Pathology·Yoo Ri KimSug Hyung Lee
Sep 19, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M S KimN J Yoo
Apr 21, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Min Sung KimSug Hyung Lee
Dec 23, 2009·Pathology·Ji Eun OhNam Jin Yoo
Feb 11, 2009·Cancer Letters·Yulia M UlybinaEvgeny N Imyanitov
May 7, 2015·Clinical and Experimental Immunology·B FloodE M Creagh
Jul 19, 2011·The American Journal of Pathology·Dorian R A SwartsErnst-Jan M Speel
May 6, 2014·Frontiers in Physiology·Patrick F ConnollyHoward O Fearnhead
Feb 16, 2017·Frontiers in Pharmacology·Somayeh KhazaeiPatimah Ismail
Dec 19, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Somayeh KhazaeiPatimah Ismail
Nov 6, 2018·Scientific Reports·Xuguo Zhu, Shuangqi Li
Mar 28, 2019·Aging Cell·Kimberley A WigginsMurray C H Clarke
Apr 21, 2020·Cancer Medicine·Jun LuoYaoting Xu
Sep 29, 2020·PeerJ·Sarah Albogami
Apr 30, 2017·Oncology Letters·Misako ShibamotoKoshi Mimori
Aug 12, 2020·Cancer Medicine·Qianwei XingYi Wang
Mar 22, 2014·Biomedical Reports·Ying-Li PanXing Liu
May 30, 2020·International Journal of Molecular Sciences·Christian Sordo-BahamondeAlejandro López-Soto
Jul 25, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiasi WuXianli Meng
Jul 21, 2017·Biochemistry·Kevin B DagbayJeanne A Hardy