Mutational analysis of IgVH and BCL-6 genes suggests thymic B-cells origin of mediastinal (thymic) B-cell lymphoma

Leukemia & Lymphoma
Balázs CsernusAndrás Matolcsy

Abstract

Mediastinal (thymic) large B-cell lymphoma (MBL) has been defined as a subtype of diffuse large B-cell lymphoma (DLBL) arising in the mediastinum with characteristic clinicopathological features. It has been postulated that MBL arise from non-circulating thymic B-cells and represent a distinct lymphoma entity, however, the histogenesis of the disease is not yet fully understood. In order to clarify the histogenetic derivation of MBL and to determine the relationship of MBL to thymic B-cells we have analyzed the nucleic acid sequences of immunoglobulin (Ig) heavy chain variable region (VH) and 5' noncoding region of BCL-6 genes in normal thymic B-cells and six cases of MBL. Thymic B-cells and tumor cells of MBLs displayed hypermutated VH and/or BCL-6 genes but intraclonal divergence did not associate with these mutations. Since somatic mutations of the IgVH and BCL-6 genes are histogenetic markers of B-cell transit through the germinal centre (GC), these results suggest that both thymic B-cells and MBLs derived from GC or an equivalent environment where B-cells underwent somatic hypermutation. The similar pattern of mutations of IgVH and BCL-6 genes found in thymic B-cells and MBLs further supports the theory that MBLs originate...Continue Reading

References

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Citations

May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alberto ZamòFabio Menestrina
Dec 17, 2008·Hematology·Peter W M Johnson, Andrew J Davies
Nov 14, 2014·Leukemia & Lymphoma·David D W Twa, Christian Steidl
Jun 28, 2011·Blood·Christian Steidl, Randy D Gascoyne
May 25, 2006·The Oncologist·Kerry J Savage
Sep 20, 2015·American Journal of Clinical Pathology·Olga K WeinbergRobert S Ohgami
Feb 12, 2019·British Journal of Haematology·Charlotte LeesJay Gunawardana

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