Abstract
The phosphoinositide 3-kinase (PIK3)/v-akt murine thymoma (AKT) oncogene pathway and the RAS/RAF pathway are involved in regulating the signalling of multiple biological processes, including apoptosis, metabolism, cell proliferation, and cell growth. Mutations in the genes within these pathways are frequently found in several tumours. The aim of this study was to investigate the frequency of mutations in the PIK3CA, BRAF, and KRAS genes in cases of malignant salivary gland tumours. Mutational analysis of the PIK3CA, KRAS, and BRAF genes was performed by direct sequencing of material from 21 patients with malignant salivary gland tumours who underwent surgery between 1992 and 2001. No mutations were found in the KRAS exon 2, BRAF exon 15, or PIK3CA exon 9 genes. However, an unpublished mutation of the PIK3CA gene in exon 20 (W1051 stop mutation) was found in one case of adenocarcinoma NOS. The impact of this mutation on the biological behaviour of the tumour has yet to be explored, however the patient with adenocarcinoma NOS harbouring this mutation has survived for over 20 years following surgery despite a high stage at presentation. Further studies with more homogeneous patient cohorts are needed to address whether this mutati...Continue Reading
References
May 9, 2000·Cancer Letters·Y M JengH C Hsu
Jan 23, 2003·Nature Genetics·Giovanni TononFrederic J Kaye
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wanglong QiuGloria H Su
Jan 20, 2009·Recent Patents on Anti-cancer Drug Discovery·Kwong-Kwok Wong
Apr 14, 2009·Oral Oncology·Regine DahseHartwig Kosmehl
Jun 24, 2009·Journal of Biomedicine & Biotechnology·Regine DahseHartwig Kosmehl
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michelle D WilliamsAdel K El-Naggar
Sep 4, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Karl C BruckmanGloria H Su
Aug 10, 2011·Oral Oncology·Yoram CohenAbraham Hirshberg
Jul 31, 2012·Oral and Maxillofacial Surgery·Tobias EttlTorsten E Reichert
Nov 29, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valentina NardiDora Dias-Santagata
Jul 16, 2013·The American Journal of Surgical Pathology·Christopher C GriffithSimion I Chiosea
Sep 23, 2014·Nature Genetics·Ilan WeinrebJorge S Reis-Filho
Oct 26, 2014·Journal of Translational Medicine·Bo Mi KuMyung-Ju Ahn
Dec 30, 2014·Genes, Chromosomes & Cancer·Isabel FonsecaDiana Bell
Citations
May 11, 2012·PloS One·Margrét H ÖgmundsdóttirDeborah C I Goberdhan
Mar 1, 2012·PloS One·Stephen R SpindlerFrank Sauer
Oct 21, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Magdalena BodnarAndrzej Marszalek
Apr 24, 2018·Oncotarget·Kosuke SaidaHiroshi Inagaki