Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas

Japanese Journal of Cancer Research : Gann
Y ImaiT Ishikawa

Abstract

Because combined hepatocellular-cholangiocellular carcinoma is rare and its biological features and pathogenesis have not been well established, we investigated alterations of the p53, K-ras and Rb-1 genes, as well as expression patterns of carcinoembryonic antigen and keratin, in seven combined hepatocellular-cholangiocarcinomas out of 557 hepatocellular carcinomas autopsied at Tokyo University during 30 years. Mutations of the p53 gene were found in two cases, at codon 244 (GGC to TGC) in the cholangiocellular carcinoma component of case 1 (mixed type, showing an intimate intermingling of both elements) and at codon 234 (TAC to AAC) in both components of case 5 (combined type, consisting of contiguous but independent masses of both elements). Mutation of the K-ras gene (codon 12, GGT to GAT) was seen only in the cholangiocellular carcinoma component of clinically apparent double cancer, case 6. Allelic alteration of the Rb-1 gene was observed in two cases, deletion of both alleles in the hepatocellular carcinoma component of case 3 (combined type) and replication error of the same pattern in both components of case 4 (mixed type). Immunohistochemical analysis showed that the hepatocellular carcinoma components of five cases (...Continue Reading

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Citations

Sep 28, 2010·Journal of Oncology·Jue WangAnne Kessinger
Mar 7, 2013·Gastroenterology·Jesper B Andersen, Snorri S Thorgeirsson
Mar 1, 2012·Experimental and Molecular Pathology·Huey-Ling YouWan-Ting Huang
Jul 7, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Shahid A KhanSimon D Taylor-Robinson
Aug 4, 2004·Journal of Hepatology·Dominique Cazals-HatemJessica Zucman-Rossi
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Karel CacaFrieder Berr
Dec 23, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Qiang ZuoWangjun Liao
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Sep 21, 2000·European Journal of Clinical Investigation·A TulloE Sbisà
Mar 8, 2012·Current Opinion in Gastroenterology·Jesper B Andersen, Snorri S Thorgeirsson
May 18, 2016·World Journal of Gastroenterology : WJG·An-Qiang WangHai-Tao Zhao
Mar 1, 2019·World Journal of Surgical Oncology·Jiakun WangLinquan Wu

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