Mutational analysis of the ribosome

Advances in Genetics
K L Triman

Abstract

The ribosome is responsible for protein synthesis, the translation of the genetic code, in all living organisms. Ribosomes are composed of RNA (ribosomal RNA) and protein (ribosomal protein). Soluble protein factors bind to the ribosome and facilitate different phases of translation. Genetic approaches have proved useful for the identification and characterization of the structural and functional roles of specific nucleotides in ribosomal RNA and of specific amino acids in ribosomal proteins and in ribosomal factors. This chapter summarizes examples of mutations identified in ribosomal RNA, ribosomal proteins, and ribosomal factors.

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Citations

Jul 16, 2008·Nucleic Acids Research·Hilda David-Eden, Yael Mandel-Gutfreund
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christoph LoenarzChristopher J Schofield
Sep 18, 2013·Antimicrobial Agents and Chemotherapy·Cédric OrelleAlexander S Mankin
Jul 3, 2009·Physical Biology·Ignacio Tinoco, Jin-Der Wen
Sep 16, 2016·Nature·J Wade Harper, Eric J Bennett
Dec 17, 2014·Clinical Medicine Insights. Blood Disorders·Hani NakhoulHua Lu
Aug 30, 2016·Angewandte Chemie·Stephen D FriedJason W Chin
Mar 11, 2011·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Naoto ChiharaShigeo Ohta
Oct 16, 2015·Angewandte Chemie·Stephen D FriedJason W Chin
May 2, 2013·ACS Chemical Biology·Joanna TrylskaZofia Dąbrowska
Feb 26, 2009·Cell·Hani S Zaher, Rachel Green

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