Mutational bias affects protein evolution in flowering plants

Molecular Biology and Evolution
Huai-chun WangDonal A Hickey

Abstract

Amino acid sequences from several thousand homologous gene pairs were compared for two plant genomes, Oryza sativa and Arabidopsis thaliana. The Arabidopsis genes all have similar G+C (guanine plus cytosine) contents, whereas their homologs in rice span a wide range of G+C levels. The results show that those rice genes that display increased divergence in their nucleotide composition (specifically, increased G+C content) showed a corresponding, predictable change in the amino acid compositions of the encoded proteins relative to their Arabidopsis homologs. This trend was not seen in a "control" set of rice genes that had nucleotide contents closer to their Arabidopsis homologs. In addition to showing an overall difference in the amino acid composition of the homologous proteins, we were also able to investigate the biased patterns of amino acid substitution since the divergence of these two species. We found that the amino acid exchange matrix was highly asymmetric when comparing the High G+C rice genes with their Arabidopsis homologs. Finally, we investigated the possible causes of this biased pattern of sequence evolution. Our results indicate that the biased pattern of protein evolution is the consequence, rather than the ca...Continue Reading

Citations

Oct 22, 2008·Plant Molecular Biology·Nickolai N AlexandrovKenneth A Feldmann
Sep 27, 2007·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Sumit K BagChitra Dutta
Nov 3, 2007·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Xiang Jia Min, Donal A Hickey
Jan 1, 2009·Genome Biology and Evolution·Mihai AlbuDonal A Hickey
Oct 4, 2006·Proceedings. Biological Sciences·Sylvain GléminDeborah Charlesworth
May 17, 2006·Genome Research·Liying CuiClaude dePamphilis
Feb 10, 2007·BMC Evolutionary Biology·Huai-Chun Wang, Donal A Hickey
May 18, 2010·BMC Genomics·Tatiana V TatarinovaKenneth A Feldmann
Oct 6, 2004·Genome Biology·Donal A Hickey, Gregory A C Singer
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Apr 21, 2011·Molecular Biology and Evolution·Aline MuyleSylvain Glémin
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Related Concepts

G+C Composition
Plant Proteins
Rice (Dietary)
Arabidopsis thaliana <plant>
Genome, Plant
Evolution, Molecular
Online Mendelian Inheritance In Man

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