Mutational enzymatic resistance of Enterobacter species to beta-lactam antibiotics.

Antimicrobial Agents and Chemotherapy
M F LampeJ C Sherris

Abstract

Mutants with enhanced beta-lactam resistance were selected from strains of Enterobacter cloacae and E. aerogenes by using three antibiotics. High-level beta-lactamase-producing mutants had similar degrees of increased resistance, enzyme substrate profiles, and isoelectric (pI) values irrespective of the selective agent. Reverse mutants from a resistant E. cloacae mutant regained the susceptibility pattern originally exhibited by the wild type, or were of enhanced susceptibility, and no longer expressed increased beta-lactamase production. beta-Lactamases of the mutants were similar in pI values to the wild-type enzyme. The increased resistance of the mutants therefore appeared to be accounted for by increased beta-lactamase production.

References

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Citations

Aug 1, 1987·European Journal of Clinical Microbiology·C C Sanders, W E Sanders
Jun 1, 1996·International Journal of Antimicrobial Agents·M H Nicolas-Chanoine
May 15, 2002·International Journal of Antimicrobial Agents·Thomas W Huber
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May 1, 1996·Antimicrobial Agents and Chemotherapy·J C Fung-TomcD P Bonner

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