Mutational signatures and mutable motifs in cancer genomes

Briefings in Bioinformatics
Igor B RogozinDavid N Cooper

Abstract

Cancer is a genetic disorder, meaning that a plethora of different mutations, whether somatic or germ line, underlie the etiology of the 'Emperor of Maladies'. Point mutations, chromosomal rearrangements and copy number changes, whether they have occurred spontaneously in predisposed individuals or have been induced by intrinsic or extrinsic (environmental) mutagens, lead to the activation of oncogenes and inactivation of tumor suppressor genes, thereby promoting malignancy. This scenario has now been recognized and experimentally confirmed in a wide range of different contexts. Over the past decade, a surge in available sequencing technologies has allowed the sequencing of whole genomes from liquid malignancies and solid tumors belonging to different types and stages of cancer, giving birth to the new field of cancer genomics. One of the most striking discoveries has been that cancer genomes are highly enriched with mutations of specific kinds. It has been suggested that these mutations can be classified into 'families' based on their mutational signatures. A mutational signature may be regarded as a type of base substitution (e.g. C:G to T:A) within a particular context of neighboring nucleotide sequence (the bases upstream a...Continue Reading

References

Dec 21, 1992·Journal of Theoretical Biology·W H Day, F R McMorris
Mar 11, 1992·Nucleic Acids Research·W H Day, F R McMorris
Jan 1, 1990·Environmental and Molecular Mutagenesis·M J HorsfallB W Glickman
Feb 1, 1988·Human Genetics·D N Cooper, H Youssoufian
Nov 15, 1971·JAMA : the Journal of the American Medical Association·S Benzer
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P J Gearhart, D F Bogenhagen
Jun 1, 1995·Current Opinion in Genetics & Development·R Fishel, R D Kolodner
Feb 17, 1998·European Journal of Immunology·J BachlM Wabl
Jun 26, 1998·Current Opinion in Cell Biology·T A Prolla
Jul 31, 1998·American Journal of Human Genetics·M KrawczakD N Cooper
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ToyotaJ P Issa
Sep 17, 1999·Bioinformatics·V B Berikov, I B Rogozin
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 16, 2001·Breast Cancer Research : BCR·R Scully
May 29, 2001·Nature Immunology·I B RogozinT A Kunkel
Sep 14, 2001·Journal of Molecular Biology·T MatsudaT A Kunkel
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·T TsuzukiM Sekiguchi
Oct 30, 2001·Current Opinion in Genetics & Development·M Zavolan, T B Kepler
Mar 21, 2002·Nature Reviews. Cancer·J D Rowley
Jun 4, 2002·Nature Reviews. Genetics·Peter A Jones, Stephen B Baylin
Jul 5, 2002·Nature·Svend K Petersen-MahrtMichael S Neuberger
Jun 27, 2003·Trends in Biochemical Sciences·Michael S NeubergerSvend K Petersen-Mahrt
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Jul 29, 2003·The Journal of Biological Chemistry·Polina V ShcherbakovaThomas A Kunkel
Jul 31, 2003·Mutation Research·Igor B Rogozin, Youri I Pavlov
Aug 16, 2003·Science·Vineet N KewalRamani, John M Coffin
Oct 30, 2003·Briefings in Bioinformatics·Igor B RogozinYouri I Pavlov
Jan 15, 2004·Human Mutation·Alexey S Kondrashov, Igor B Rogozin
Mar 3, 2004·Nature Reviews. Cancer·P Andrew FutrealMichael R Stratton
Mar 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jean-Philippe BrunetJill P Mesirov
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kun YuPatrick Tan
Sep 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Albino BacollaRobert D Wells
Jul 27, 2005·Seminars in Cancer Biology·Robert A Beckman, Lawrence A Loeb
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roman RouzierLajos Pusztai
Feb 16, 2006·Journal of the National Cancer Institute·Christos SotiriouMauro Delorenzi

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