Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia

Tuberculosis
Elena MartinezVitali Sintchenko

Abstract

Genome-wide analysis of 517 Mycobacterium tuberculosis isolates from New South Wales, Australia, have identified previously reported and 8 new mutations in Rv0678 and atpE genes linked to in vitro resistance to bedaquiline, a new class of antimycobacterial drugs. These mutations were present in 2.9% of prospectively sequenced genomes but in 10.6% of strains that were phenotypically multidrug-resistant. However only 14% of isolates with these mutations demonstrated elevated minimum inhibitory concentrations to bedaquiline.

Citations

Jun 17, 2020·Antimicrobial Agents and Chemotherapy·Keira A CohenAlexander S Pym
Oct 13, 2020·Frontiers in Microbiology·Giulia DegiacomiMaria Rosalia Pasca
Feb 8, 2021·European Journal of Medicinal Chemistry·Cauê Benito ScarimFernando Rogério Pavan
Jan 26, 2020·The Journal of Infection·Irina V PeretokinaDanila V Zimenkov
Mar 24, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Connie LamVitali Sintchenko
Nov 9, 2021·Frontiers in Microbiology·Sheng-Han WuRuwen Jou

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