Dec 24, 2004

Mutations causing neurodegenerative tauopathies

Biochimica Et Biophysica Acta
Michel Goedert, Ross Jakes

Abstract

Tau is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. They include the largely sporadic Alzheimer's disease (AD), progressive supranuclear palsy, corticobasal degeneration, Pick's disease and argyrophilic grain disease, as well as the inherited frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). For a long time, it was unclear whether the dysfunction of tau protein follows disease or whether disease follows tau dysfunction. This was resolved when mutations in Tau were found to cause FTDP-17. Currently, 32 different mutations have been identified in over 100 families. About half of the known mutations have their primary effect at the protein level. They reduce the ability of tau protein to interact with microtubules and increase its propensity to assemble into abnormal filaments. The other mutations have their primary effect at the RNA level and perturb the normal ratio of three-repeat to four-repeat tau isoforms. Where studied, this resulted in a relative overproduction of tau protein with four microtubule-binding domains in the brain. Individual Tau mutations give rise to diseases that resemble progressive supranuclear palsy, corticobasa...Continue Reading

  • References123
  • Citations175

Citations

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Pathogenic Aspects
Biochemical Pathway
Tauopathies
Transfection
Molecular Helix
Pathogenesis
APP protein, human
Hyperphosphorylation
Microtubule-Associated Protein 3

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