Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates

Antimicrobial Agents and Chemotherapy
Jung-Yien ChienPo-Ren Hsueh

Abstract

In order to correlate the mutations inside the entiregyrAandgyrBgenes with the level of resistance to ofloxacin (OFX) and moxifloxacin (MFX) in isolates of multidrug-resistantMycobacterium tuberculosis(MDR-TB), a total of 111 isolates were categorized into OFX-susceptible (MIC, ≤2 μg/ml) and low-level (MIC, 4 to 8 μg/ml) and high-level (MIC, ≥16 μg/ml) OFX-resistant isolates and MFX-susceptible (MIC, ≤0.5 μg/ml) and low-level (MIC, 1 to 2 μg/ml) and high-level (MIC, ≥4 μg/ml) MFX-resistant isolates. Resistance-associated mutations inside thegyrAgene were found in 30.2% of OFX-susceptible and 72.5% and 72.2% of low-level and high-level OFX-resistant isolates and in 28.6% of MFX-susceptible and 58.1% and 83.9% of low-level and high-level MFX-resistant isolates. Compared with OFX-susceptible isolates, low-level and high-level OFX-resistant isolates had a significantly higher prevalence of mutations atgyrAcodons 88 to 94 (17.0%, 65.0%, and 72.2%, respectively;P< 0.001) and a higher prevalence of thegyrBG512R mutation (0.0%, 2.5%, and 16.7%, respectively;P= 0.006). Similarly, compared with MFX-susceptible isolates, low-level and high-level MFX-resistant isolates had a significantly higher prevalence of mutations atgyrAcodons 88 to 9...Continue Reading

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Citations

Sep 7, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Paolo MiottoWing Cheong Yam
Dec 30, 2017·The European Respiratory Journal·Andrea Maurizio CabibbeGiovanni Battista Migliori
Apr 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernanda MaruriTimothy R Sterling
Feb 1, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Prabha DesikanK S Sachdeva
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Devan JaganathPeter R Donald
Dec 12, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Yan HuDaiyu Hu
Feb 20, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jingtao GaoYu Pang
Jul 28, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marzieh SafariBahram Nasr Esfahani
May 18, 2019·Journal of Global Antimicrobial Resistance·Feriel BouzianeUNKNOWN CNR-MyRMA
May 25, 2021·Computational and Structural Biotechnology Journal·Pooja SinghSeyed E Hasnain

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