Mutations in KISS1 are not responsible for idiopathic hypogonadotropic hypogonadism in Chinese patients

Journal of Assisted Reproduction and Genetics
Yiming ZhangZi-Jiang Chen

Abstract

To investigate whether mutations in the KISS1 gene are present in 170 Chinese patients with idiopathic hypogonadotropic hypogonadism (IHH). Mutational screening of the KISS1 gene was performed in 170 Chinese patients with IHH (133 male cases and 37 female cases) and 187 matched controls (94 males and 93 females). Two known single-nucleotide polymorphisms (SNP), c. 58G > A in exon 1 and c. 242C > G in exon 2, were identified. However, no difference of genotype and allelic frequencies between cases and controls was observed. The results suggest that mutations in the coding sequence of KISS1 are not common in patients with IHH in this Chinese population.

References

Dec 4, 1996·Journal of the National Cancer Institute·J H LeeD R Welch
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Waljit S DhilloStephen R Bloom
Feb 27, 2007·Reviews in Endocrine & Metabolic Disorders·Waljit S DhilloStephen R Bloom
Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·J T Smith, I J Clarke
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xavier d'Anglemont de TassignyWilliam H Colledge
Jun 28, 2007·Endocrinology·Risto LapattoStephanie B Seminara
Jul 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Waljit S DhilloStephen R Bloom
Jan 15, 2008·Results and Problems in Cell Differentiation·W H Colledge
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle L GottschRobert A Steiner
Aug 27, 2009·Nature Reviews. Endocrinology·Suzy D C Bianco, Ursula B Kaiser
Feb 11, 2010·Molecular and Cellular Endocrinology·Zofia K Z GajdosMark R Palmert
Mar 9, 2010·European Journal of Endocrinology·Frédéric BrioudeJacques Young
Mar 20, 2010·The Journal of Clinical Endocrinology and Metabolism·L G SilveiraA C Latronico
Jan 7, 2011·The Journal of Clinical Endocrinology and Metabolism·Natalie D ShawJanet E Hall
Apr 23, 2011·Trends in Endocrinology and Metabolism : TEM·Anna L MitchellRichard Quinton
Apr 26, 2011·Nature Neuroscience·Christian Mayer, Ulrich Boehm
Jun 15, 2011·Molecular and Cellular Endocrinology·Margaret G AuCassandra L Buck
Jun 15, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·L AnselV Simonneaux
Feb 18, 2012·The New England Journal of Medicine·A Kemal TopalogluBilgin Yuksel
Mar 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Jacques Young
Jul 7, 2012·Journal of Clinical Research in Pediatric Endocrinology·Fatih GürbüzAli Kemal Topaloğlu
Sep 19, 2012·Journal of Clinical Research in Pediatric Endocrinology·D Bahar GençAtilla Büyükgebiz
Jul 3, 2013·Nature Reviews. Endocrinology·Robert P Millar, Claire L Newton
Aug 24, 2013·International Journal of Molecular Medicine·Ke JiWen G Jiang
Sep 4, 2013·Hormones and Behavior·Miguel A Sanchez-Garrido, Manuel Tena-Sempere
Dec 21, 2013·Neuroendocrinology·P GrachevK T O'Byrne
Mar 13, 2014·Human Reproduction Update·Karolina SkorupskaiteRichard A Anderson

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Citations

Dec 15, 2020·British Journal of Biomedical Science·M FarsimadanH Vaziri

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