PMID: 11604081Oct 18, 2001Paper

Mutations in mammalian cells induced by heavy charged particles: an indicator for risk assessment in space

Radiation Research
J KieferS Koch

Abstract

Induction of mutations at the HPRT locus in V79 Chinese hamster cells by heavy charged particles is reviewed. A unique dependence of mutation induction cross sections on LET or any other physical parameter of the particles cannot be found. There is, however, a general trend showing an increase up to about 100 keV/microm and an indication of a saturation with higher LET. An empirical expression is given approximating the data which may be useful for practical purposes. On the basis of this expression, it is suggested that the formula used by the ICRP for the quality factor overestimates the risk for very heavy particles. This may have implications for the assessment of the risk of exposure to iron ions in space.

References

Dec 1, 1990·International Journal of Radiation Biology·T KranertJ Kiefer
Jun 1, 1995·Radiation and Environmental Biophysics·A KronenbergC A Waldren
Jun 1, 1995·Radiation and Environmental Biophysics·U StollJ Kiefer
Jan 1, 1994·International Journal of Radiation Biology·R Cox
Jul 1, 1996·International Journal of Radiation Biology·U StollJ Kiefer
Jan 15, 2000·Mutation Research·J KieferP Schmidt

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Citations

Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·K GeorgeF A Cucinotta
Nov 15, 2003·Annals of the ICRP·UNKNOWN Task Group on Radiation Quality Effects in Radiological Protection, Committee 1 on Radiation Effects, International Commissi
Jun 23, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W K Weyrather, G Kraft
Aug 8, 2014·Radiation Research·Janapriya SahaFrancis A Cucinotta
Jun 23, 2016·Radiation Research·A C HeuskinS V Costes
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Jürgen Kiefer
Apr 29, 2005·Uchū Seibutsu Kagaku·Fumio Yatagai
Feb 12, 2002·Radiation Research·Jürgen KieferSamuel Ikpeme
Jun 10, 2003·Journal of Radiation Research·Juergen Kiefer
Oct 14, 2003·International Journal of Radiation Biology·Y YokotaM Inoue

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