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Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activate Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Karina CalvopiñaMatthew B. Avison

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Abstract

Aminoglycoside resistance in Stenotrophomonas maltophilia is multifactorial, but the most significant mechanism is overproduction of the SmeYZ efflux system. By studying laboratory selected mutants and clinical isolates, we show here that damage to the 50S Ribosomal protein L1 (RplA) ac...read more

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Antibiotics
Laboratory
Minocycline
Ribosomal Proteins
Ribosomes
Ribosomal protein L1
Ion Pumps
Internal
Stenotrophomonas maltophilia
Mutant
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Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activate Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

Karina CalvopiñaMatthew B. Avison

PMID: 31712205

DOI: 10.1128/aac.01524-19

Abstract

Aminoglycoside resistance in Stenotrophomonas maltophilia is multifactorial, but the most significant mechanism is overproduction of the SmeYZ efflux system. By studying laboratory selected mutants and clinical isolates, we show here that damage to the 50S Ribosomal protein L1 (RplA) ac...read more

Mentioned in this Paper

Antibiotics
Laboratory
Minocycline
Ribosomal Proteins
Ribosomes

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