Nov 13, 2019

Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activates Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy
Karina CalvopiñaMatthew B Avison

Abstract

Aminoglycoside resistance in Stenotrophomonas maltophilia is multifactorial, but the most significant mechanism is overproduction of the SmeYZ efflux system. By studying laboratory-selected mutants and clinical isolates, we show here that damage to the 50S ribosomal protein L1 (RplA) activates SmeYZ production. We also show that gentamicin and minocycline, which target the ribosome, induce expression of smeYZ These findings explain the role of SmeYZ in both intrinsic and mutationally acquired aminoglycoside resistance.

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Mentioned in this Paper

Aminoglycoside [EPC]
Ribosomal Proteins
Laboratory
Ion Pumps
Ribosomes
Minocycline
Stenotrophomonas maltophilia
Ribosomal protein L1
Resistance Process
Isolate - Microorganism

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