Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse

Genomics
Dominique Simon-ChazottesJean-Louis Guénet

Abstract

Positional cloning of two recessive mutations of the mouse that cause polysyndactyly (dan and mdig-Chr 2) confirmed that the gene encoding MEGF7/LRP4, a member of the low-density lipoprotein receptor family, plays an essential role in the process of digit differentiation. Pathologies observed in the mutant mice provide insight into understanding the function(s) of LRP4 as a negative regulator of the Wnt-beta-catenin signaling pathway and may help identify the genetic basis for common human disorders with similar phenotypes.

References

Jun 21, 2002·Trends in Cell Biology·Anders Nykjaer, Thomas E Willnow
Apr 26, 2003·Traffic·Petra May, Joachim Herz
Mar 17, 2004·Current Opinion in Lipidology·Joachim Herz, David Y Hui
Jul 10, 2004·Developmental Biology·Maja AdamskaMiriam H Meisler
Sep 15, 2005·Cellular and Molecular Life Sciences : CMLS·P MayH H Bock
Oct 7, 2005·Human Molecular Genetics·Eric B JohnsonJoachim Herz

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Citations

Jul 1, 2014·Journal of Hip Preservation Surgery·Vickas Khanna, Paul E Beaulé
Nov 20, 2008·Journal of Lipid Research·Joachim HerzLi Zhou
Sep 28, 2010·Biological Chemistry·Marco DieckmannJoachim Herz
Apr 8, 2011·The Journal of Biological Chemistry·Olivier LeupinMichaela Kneissel
Jan 1, 2012·BoneKEy Reports·Mark L Johnson
Dec 25, 2008·Molecular Genetics and Genomics : MGG·Adrienn BorsyLászló Orosz
Jul 21, 2010·Current Opinion in Rheumatology·Julie C Baker-LePain, Nancy E Lane
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·Yinong Zong, Rongsheng Jin
Aug 5, 2011·Journal of Neurology·Alexandra PevznerStephan Kröger
May 15, 2013·European Journal of Medical Genetics·Tahir Naeem KhanN Dahl
Nov 15, 2011·Gene·David G MonroeJennifer J Westendorf
Nov 26, 2010·American Journal of Medical Genetics. Part a·Atsushi OhazamaPaul T Sharpe
Sep 25, 2007·Brain Research·Yonghao LuTatsuo Suzuki
Aug 4, 2015·Developmental Biology·Kristina PalmerStephen A Murray
Jun 7, 2015·Reviews in Endocrine & Metabolic Disorders·N Lara-Castillo, M L Johnson
Aug 6, 2014·Biochemical and Biophysical Research Communications·Nobuyuki AsaiKinji Ohno
Feb 14, 2015·Journal of Medical Genetics·Nisha PatelFowzan S Alkuraya
Oct 30, 2008·Neuron·Bin ZhangLin Mei
Feb 26, 2013·Seminars in Arthritis and Rheumatism·Eveline BoudinWim Van Hul
Mar 17, 2017·Frontiers in Molecular Neuroscience·Theresa PohlkampJoachim Herz
Jun 4, 2014·Therapeutic Advances in Musculoskeletal Disease·Gaël Y Rochefort
Jun 1, 2012·Current Protocols in Mouse Biology·Muriel T DavissonLeah Rae Donahue
Mar 27, 2012·The Open Orthopaedics Journal·D JordanW Khan
Oct 11, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Shinji SasakiTakatoshi Kojima
Jun 23, 2012·Endocrine Reviews·Hua Zhu KeMichael S Ominsky
Aug 17, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Juan A MonteroJuan M Hurle
May 29, 2018·International Journal of Endocrinology·Sarah-Kim BissonFabrice Mac-Way
May 2, 2017·Genes & Genomics·Aleksandra CiepłochEwa Poławska
Apr 4, 2021·Journal of Developmental Biology·Alison T DePew, Timothy J Mosca

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